858006-31-2

Usage

Physical state

Colorless to pale yellow solid at room temperature

Solubility

Sparingly soluble in water

Uses

a. Intermediate in the production of pharmaceuticals
b. Intermediate in the production of agrochemicals
c. Intermediate in the production of dyes
d. Reagent in organic synthesis
e. Production of aromatic compounds

Health and environmental hazards

a. Toxic if ingested
b. Toxic if inhaled
c. Toxic in contact with skin
d. Harmful to aquatic life

Safety measures

Appropriate safety measures and regulations should be followed when handling this chemical

Upstream product

• 108-36-1 1,3-dibromobenzene 
• 67713-23-9 2,6-dibromobenzaldehyde 
• 1013031-65-6 (2,6-dibromophenyl)methanol 

Downstream Products

• 1013031-65-6 (2,6-dibromophenyl)methanol 
• 67197-53-9 2-(2,6-dibromophenyl)acetonitrile 
• 601-84-3 2,6-dibromobenzoic acid 

Relevant academic research and scientific papers

Preparation process 2-6 - dibromobenzoyl chloride

The invention discloses a preparation process for 2,6-dibromobenzene methylsulfonyl chloride. The preparation process comprises the following steps: with m-dibromobenzene as a starting raw material, subjecting the m-dibromobenzene to a five-step reaction of acylation, reduction, chlorine substitution, substitution and sulfonyl chlorination so as to obtain a target compound namely the 2,6-dibromobenzene methylsulfonyl chloride. The process provided by the invention uses cheap and easily-available raw materials, has good safety by using NCS to replace chlorine gas as a chlorinating agent, and facilitates practical application.

KRAS G12C INHIBITORS

The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.