858666-87-2

Upstream product

• 852244-95-2 (2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one 
• 858666-85-0 (2S,9S,10S)-(-)-1-benzyloxy-2,9-bis-(tert-butyldimethylsilyloxy)-11-(tert-butyldiphenylsilyloxy)-10-methylundecane-5-one 
• 56-86-0 L-glutamic acid 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 32780-08-8 (5S)-5-[(benzyloxy)methyl]dihydrofuran-2(3H)-one 
• 852244-90-7 (4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 852244-93-0 tert-Butyl-[(2S,3S)-6-iodo-3-(4-methoxy-benzyloxy)-2-methyl-hexyloxy]-diphenyl-silane 
• 852244-92-9 (4S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5-methyl-hexan-1-ol 
• 852244-89-4 (4R,5S)-3-((2R,3S)-6-Benzyloxy-3-hydroxy-2-methyl-hexanoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 852244-91-8 (2S,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexan-1-ol 
• 852244-94-1 (S)-5-Benzyloxy-4-(4-methoxy-benzyloxy)-pentanoic acid methoxy-methyl-amide 
• 852245-14-8 (S)-5-Benzyloxy-4-hydroxy-pentanoic acid methoxy-methyl-amide 
• 786668-40-4 (2S,3S)-(-)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-2-methylheptan-3-ol 
• 786668-23-3 (2S,3S)-(+)-7-benzyloxy-2-methylheptane-1,3-diol 

Downstream Products

• 858666-89-4 (2S,5S,7S,1''S)-(+)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-2-hydroxymethyl-1,6-dioxaspiro[4.5]decane 
• 931113-66-5 3-((2S,3S)-3-{(2S,5S,7S)-7-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-1,6-dioxa-spiro[4.5]dec-2-yl}-2-methyl-oxiranyl)-2-hydroxy-propionic acid methyl ester 
• 887001-91-4 (2S,5S,7S,1'S,2'S,1''S)-(+)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-2-(1',2'-epoxy-3'-iodo-2'-methylprop-1'-yl)-1,6-dioxaspiro[4.5]decane 
• 858666-63-4 (1'E,2S,5R,7S,1''S)-(+)-2-(6'-benzyloxy-2'-methyl-1'-hexen-4'-yn-1'-yl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane 
• 858666-95-2 tert-Butyl-{(S)-2-[(2S,5R,7S)-2-((E)-3-iodo-2-methyl-propenyl)-1,6-dioxa-spiro[4.5]dec-7-yl]-propoxy}-diphenyl-silane 
• 858666-91-8 (1'E,2S,5R,7S,1''S)-(+)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-2-(2'-ethoxycarbonyl-2'-methyl-1'-propenyl)-1,6-dioxaspiro[4.5]decane 
• 887001-90-3 (2S,5S,7S,1'S,2'S,1''S)-(+)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-2-(1',2'-epoxy-3'-hydroxy-2'-methylprop-1'-yl)-1,6-dioxaspiro[4.5]decane 
• 858666-93-0 (1'E,2S,5R,7S,1''S)-(+)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-2-(3'-hydroxy-1'-propenyl)-1,6-dioxaspiro[4.5]decane 
• 858666-65-6 (2S,5S,7S,1''S)-(+)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-2-formyl-1,6-dioxaspiro[4.5]decane 

Relevant academic research and scientific papers

Synthesis of the ABC tricyclic fragment of the pectenotoxins via stereocontrolled cyclization of a γ-hydroxyepoxide appended to the AB spiroacetal unit

The stereocontrolled synthesis of the C1-C16 ABC spiroacetal-containing tricyclic fragment of pectenotoxin-7 6 has been accomplished. The key AB spiroacetal aldehyde 9 was successfully synthesized via acid catalyzed cyclization of protected ketone precurs

Synthesis of the ABC fragment of the pectenotoxins

(Chemical Equation Presented) A highly stereocontrolled synthesis of the C1-C16 ABC spiroacetal-containing fragment 5 of PTX7 (4) has been achieved. Appendage of the C ring to the AB fragment involved Wittig reaction of spiroacetal aldehyde 8 with a stabi

Pectenotoxin-2 synthetic studies. 2. Construction and conjoining of ABC and DE eastern hemisphere subtargets

(Chemical Equation Presented) Practical asymmetric synthesis of aldehyde 2 and tetrazolyl sulfone 3 has allowed for their coupling via Julia olefination to generate 32 as a single product. This substance possesses the entire carbon backbone of the A-E substructure of pectenotoxin-2.