858860-02-3

Basic information

• Product Name: 2,3,6-Trifluoro-4-methoxypyridine
• Synonyms: 2,3,6-Trifluoro-4-methoxypyridine;4-methoxy-2,3,6-trifluoropyridine;Pyridine,2,3,6-trifluoro-4-Methoxy-
• CAS NO: 858860-02-3
• Molecular Formula: C6H4F3NO
• Molecular Weight: 163.1
• Mol File: 858860-02-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 155.9±35.0℃ (760 Torr)
• Flash Point: 48.1±25.9℃
• Appearance: /
• Density: 1.367±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 2,3,6-Trifluoro-4-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,6-Trifluoro-4-methoxypyridine(858860-02-3)
• EPA Substance Registry System: 2,3,6-Trifluoro-4-methoxypyridine(858860-02-3)

Safety Data

• Hazardous Substances Data: 858860-02-3(Hazardous Substances Data)

Usage

General Description

2,3,6-Trifluoro-4-methoxypyridine is a chemical compound that is commonly used as a reagent in various organic synthesis reactions. It is a pyridine derivative with three fluorine atoms and a methoxy group attached to the pyridine ring. 2,3,6-Trifluoro-4-methoxypyridine has a strong electron-withdrawing effect due to the presence of the fluorine atoms, making it useful in reactions that require a nucleophilic substitution or electrophilic aromatic substitution. It is also used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals due to its versatile reactivity. 2,3,6-Trifluoro-4-methoxypyridine is a valuable tool in the field of organic chemistry and is widely utilized in the production of various complex organic compounds.

Upstream product

• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 3512-13-8 2,3,4,6-tetrafluoropyridine 
• 124-41-4 sodium methylate 

Downstream Products

• 858860-03-4 2,5,6-trifluoro-4-methoxy-nicotinic acid benzyl ester 

Relevant articles and documents

Design and synthesis of fluorinated iron chelators for metabolic study and brain uptake

A range of fluorinated 3-hydroxypyridin-4-ones has been synthesized where fluorine or fluorinated substituent was attached at 2- or 5- position of the pyridine ring in order to improve chemical and biological properties of 3-hydroxypyridin-4-ones. The synthetic route is different from conventional counterparts where a functional group is introduced to a preformed 3-hydroxypyridin-4-one ring. Herein, we introduce a novel method which starts with a fluorine containing precursor and the two hydroxyl groups at 3- and 4- positions of the pyridine ring are introduced at a later stage. The pK a values of the free ligands and the affinity constants of their iron complexes demonstrate that the presence of fluorine dramatically alters the values. The distribution coefficient values of the free ligands and corresponding iron(III) complexes between 1-octanol and MOPS buffer (pH 7.4) are also influenced. Glucuronidation and oxidation studies of selected fluorinated 3-hydroxypyridin-4-ones demonstrate that some such fluorinated compounds have clear advantage over deferiprone in that they are metabolized more slowly. Blood-brain barrier permeability studies indicated that although lipophilicity influences the permeability it is not the only factor. Two of the selected seven fluorinated 3-hydroxypyridin-4-ones have improved brain distribution when compared with deferiprone.

Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro- 1,8-naphthyridone-3-carboxylic acid derivatives

A series of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3- carboxylic acid derivatives were prepared and evaluated for cell-free bacterial protein synthesis inhibition and whole cell antibacterial activity. When compared to the analogous 5-hydroge

Mechanisms for Reactions of Halogenated Compounds. Part 3. Variation in Activating Influence of Halogen Substituents in Nucleophilic Aromatic Substitution

Rate constants are reported for reactions of polyhalogeno-pyridines and -benzenes with sodium methoxide in methanol.Relative activating effects of individual fluorine and chlorine atoms at positions ortho, meta, and para to the reaction site are determined and compared with orders determined from reactions involving ammonia in aqueous dioxan.The results are remarkably similar.Additional support is provided for earlier explanations of the activating effects of ortho-fluorine and -chlorine.Activation parameters, determined for reactions of polyhalogenepyridines with ammonia in aqueous dioxan, clearly demonstrate that differences in reactivity along the series arise mainly from changes in activation energy.