85903-37-3Relevant academic research and scientific papers
Synthesis and antibacterial activity of novel 5-(heteroaryl)isoxazole derivatives
RamaRao, R. Janaki,Rao, A.K.S. Bhujanga,Sreenivas,Kumar, B. Suneel,Murthy
experimental part, p. 243 - 250 (2011/06/26)
The synthesis, characterization and antibacterial activity of novel isoxazole derivatives were reported. 3-Di (alkylamino)acryloalkanones were prepared and used as synthons to get the target isoxazole derivatives via reaction with hydroxylamine hydrochloride or hydroxylamine-O-sulphonic acid.
New isoxazole derivatives designed as nicotinic acetylcholine receptor ligand candidates
Silva, Nilda M,Tributino, Jorge L.M,Miranda, Ana L.P,Barreiro, Eliezer J,Fraga, Carlos A.M
, p. 163 - 170 (2007/10/03)
In this work we report the synthesis and evaluation of the analgesic properties of new isosteric heterocyclic derivatives, presenting the isoxazole nucleus, designed as nicotinic acetylcholine receptor ligand candidates, analogues to alkaloid epibatidine. Compound 2-(3-methyl-5-isoxazolyl)pyridine (3) presented the best analgesic profile of this series in hot plate test, which was partially prevented by pretreatment with nicotinic receptor antagonist mecamylamine.
Condensed heteroaromatic ring systems. XIX. Synthesis and reactions of 5-(tributylstannyl)isoxazoles
Sakamoto, Takao,Kondo, Yoshinori,Uchiyama, Daishi,Yamanaka, Hiroshi
, p. 5111 - 5118 (2007/10/02)
3-Substituted 5-(tributylstannyl)isoxazoles were newly synthesized by the 1,3-dipolar cyctoadditton of nitrile oxides to tributylethynylstannane. The iodination and the palladium-catalyzed benzoylation of 5-(tributylstannyl)-3-methylisoxazolegave 5-iodo-3-methylisoxazole and 3-methyl-5-isoxazolyl phenyl ketone in satisfactory yields, respectively. The palladium-catalyzed cross-coupling reaction of the stannylisoxazole with 2-bromonitrobenzene followed by the catalytic hydrogenation over Raney nickel resulted in the formation of 2-methyll-4(1H)-quinolinone in 57% overall yield.
SYNTHESIS AND REACTIONS OF 5-(TRIBUTYLSTANNYL)ISOXAZOLES
Kondo, Yoshinori,Uchiyama, Daishi,Sakamoto, Takao,Yamanaka, Hiroshi
, p. 4249 - 4250 (2007/10/02)
3-Substituted 5-(tributylstannyl)isoxazoles were synthesized in good yields by the 1,3-dipolar cycloaddition reaction of ethynyltributylstannane with nitrile oxides generated in situ. 3-Methyl-5-(tributylstannyl)isoxazole was easily converted to the corre
STUDIES ON ISOMERIC PYRIDYLISOXAZOLES
Belgodere, Elena,Bossio, Ricardo,Sio, Francesco De,Marcaccini, Stefano,Pepino, Roberto
, p. 501 - 504 (2007/10/02)
Data concerning the reaction between hydroxylamine hydrochloride and 1-(2-pyridyl)-3-phenyl- (I a) and 1-(2-thienyl)-3-phenyl-1,3-propanedione (I l) disagree with those previously reported in literature.The same reaction was also studied employing a series of 1,3-diketones-1-(pyridyl)-substituted I b-i.The direction of enolization of 1,3-diketones accounted for the isomeric isoxazoles formation.
