859140-20-8

Basic information

• Product Name: 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine
• Synonyms: 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine
• CAS NO: 859140-20-8
• Molecular Weight: 621.137
• Mol File: 859140-20-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine(859140-20-8)
• EPA Substance Registry System: 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine(859140-20-8)

Safety Data

• Hazardous Substances Data: 859140-20-8(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 4385-76-6 4-(4-pyridinyl)benzoic acid 
• 17422-33-2 6-chloroindole 
• 231295-53-7 6-chloro-1-(phenylsulfonyl)indole 
• 249292-39-5 6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonyl chloride 
• 222986-36-9 1-(tert-butoxycarbonyl)-4-[4-(4-pyridyl)benzoyl]piperazine 

Downstream Products

• 249292-06-6 1-[(6-chloroindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine 

Relevant articles and documents

Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites

Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral analysis. Modification of lead compound 7 by transformation of its N-oxide 6-6 biaryl ring system and fused aromatics produced a series of non-basic fXa inhibitors with excellent potency in anti-fXa and anticoagulant assays. The optimized compounds 73b and 75b showed sub to one digit micromolar anticoagulant activity (PTCT2). Particularly, anti-fXa activity was detected in plasma of rats orally administered with 1 mg/kg of compound 75b.