859205-33-7

Basic information

• Product Name: 1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbonitrile
• Synonyms: 1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbonitrile
• CAS NO: 859205-33-7
• Molecular Weight: 296.349
• Mol File: 859205-33-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbonitrile(859205-33-7)
• EPA Substance Registry System: 1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbonitrile(859205-33-7)

Safety Data

• Hazardous Substances Data: 859205-33-7(Hazardous Substances Data)

Usage

General Description

1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbonitrile is a chemical compound that belongs to the group of organic compounds known as indoles. Indoles are compounds containing an indole, which is a bicyclic molecule made up of a benzene ring fused to a pyrrole ring. This specific compound is characterized by additional features including a sulfonyl group (-SO2-) attached to a methylphenyl group, and a carbonitrile group (-CN) connected to the indole nucleus. While there's not much detailed information available about its specific properties and uses, this compound, like most sulfonyl compounds, is likely to display various biological activities and could have potential applications in pharmaceutical science.

Upstream product

• 67593-11-7 1-[(4-methylphenyl)sulfonyl]indol-3-ylmethanol 
• 31271-90-6 1-(p-toluenesulfonyl)-1H-indole 
• 7677-24-9 trimethylsilyl cyanide 
• 21978-63-2 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate 
• 2592-05-4 1H-indole-3-carboxaldehyde oxime 
• 506-68-3 bromocyane 
• 106-95-6 allyl bromide 
• 52670-38-9 2-ethynylaniline 
• 5457-28-3 3-cyano-1H-indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 188988-42-3 1-(Toluene-4-sulfonyl)-1H-indole-3-carbaldehyde oxime 
• 50562-79-3 1-(4-tolylsulfonyl)indole-3-carboxaldehyde 

Downstream Products

• 134029-45-1 Nortopsentin-C 
• 5457-28-3 3-cyano-1H-indole 
• 31271-90-6 1-(p-toluenesulfonyl)-1H-indole 

Relevant articles and documents

Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: From batch to flow chemistry

1,3-Dipolar dearomatizing cycloadditions between a non-stabilized azomethine ylide and 3-cyanoindoles or benzofuran afford the corresponding 3D-heterocycles bearing a quaternary carbon centre at the ring junction. While 6 equivalents of ylide precursor 1 are required for full conversion in a classical flask, working under flow conditions limits the excess (3 equiv., tR = 1 min) and leads to a cleaner process, affording cycloadducts that are easier to isolate.

Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO

A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.

Marine-Natural-Product Development: First Discovery of Nortopsentin Alkaloids as Novel Antiviral, Anti-phytopathogenic-Fungus, and Insecticidal Agents

Nortopsentin alkaloids were found to have potent antiviral, anti-phytopathogenic-fungus, and insecticidal activities for the first time. Antiviral-activity tests revealed that these compounds were very sensitive to substituents, so a series of nortopsentin derivatives were designed, synthesized, and systematically evaluated for their antiviral activities against TMV, their fungicidal activities, and their insecticidal activities on the basis of a structural-diversity-derivation strategy. Compounds 2e (in vivo inactivation-, curative-, and protective-activity inhibitory rates of 50, 59, and 56%, respectively, at 500 μg/mL) and 2k (in vivo inactivation-, curative-, and protective-activity inhibitory rates of 60, 58, and 52%, respectively, at 500 μg/mL), with excellent antiviral activities and good physicochemical properties, emerged as new lead compounds for novel-antiviral-agent development. Further fungicidal-activity tests revealed that these alkaloids displayed broad-spectrum fungicidal activities. Compounds 2f, 2h, and 2j emerged as new lead compounds for antifungal-activity research. Additionally, all the compounds displayed good insecticidal activities against five kinds of insects, including Mythimna separate, Helicoverpa armigera, Ostrinia nubilalis, Plutella xylostella, and Culex pipiens pallens.