21978-63-2

Basic information

• Product Name: 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate
• Synonyms: 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate
• CAS NO: 21978-63-2
• Molecular Weight: 289.315
• Mol File: 21978-63-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate(21978-63-2)
• EPA Substance Registry System: 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate(21978-63-2)

Safety Data

• Hazardous Substances Data: 21978-63-2(Hazardous Substances Data)

Upstream product

• 2592-95-2 benzotriazol-1-ol 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 154561-22-5 Z-Aib-OBt 
• 68930-15-4 1-(benzyloxy)-1H-benzo[d][1,2,3]triazole 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 77204-11-6 1-allyloxy-1H-benzo[d][1,2,3]triazole 
• 4873-09-0 allyl tosylate 
• 57223-16-2 1-ethoxy-1H-benzo[d]-1,2,3-triazole 
• 22713-34-4 1-methoxy-1H-benzo[d][1,2,3]triazole 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 4809-56-7 N-(1-phenylethyl)-p-toluenesulfonamide 
• 2645-02-5 methyl tosylglycinate 
• 1907-65-9 N-butyl-4-toluenesulfonamide 
• 80-30-8 N-cyclohexyl-p-toluenesulfonamide 
• 59724-69-5 (±)-methyl 2-(4-methylphenylsulfonamido)propanoate 
• 4703-22-4 N-tosylpiperidine 

Relevant articles and documents

Synthesis and evaluation of 1-hydroxybenzotriazole derivatives: Dual inhibitors of carbonic anhydrase ii and sodium hydrogen exchanger i

Ischemia reperfusion injury is responsible for impaired graft functioning in organ transplants, cerebral dysfunction, ischemic heart diseases, systemic inflammatory response syndrome, gastrointestinal dysfunction, and multiple organ dysfunction syndromes. Intracellular pH is critical for cell survival in ischemia reperfusion injury. Sodium hydrogen exchanger I and carbonic anhydrase II are critical in the regulation of intracellular pH. Inhibition of sodium hydrogen exchanger I and carbonic anhydrase II during reperfusion is found to ameliorate ischemia reperfusion injury separately. An attempt is made to synthesize dual inhibitors of sodium hydrogen exchanger and carbonic anhydrase to have better potential drug molecule in ischemia reperfusion injury treatment. The hydroxybenzotriazole is considered as a central pharmacophore for this dual activity and 12 derivatives are synthesized. All derivatives are tested for sodium hydrogen exchanger I and carbonic anhydrase II inhibitory activity. The tosylate derivative (12) is found to be the most potent derivative with IC50 158.7± 8.4 μM for carbonic anhydrase II and 31.07 ± 1.06 μM for sodium hydrogen exchanger I. Although the potency is less than standard drugs but this is the first report of dual inhibitor of carbonic anhydrase II and sodium hydrogen exchanger.

Synthesis of O-benzyl hydroxamates employing the sulfonate esters of N-hydroxybenzotriazole

The direct conversion of various carboxylic acids, that include sterically hindered amino acids and di-peptides, to O-benzyl hydroxamates is demonstrated using sulfonate esters of benzotriazoles under ambient and milder conditions without significant race

Sulfonamide synthesis using N-hydroxybenzotriazole sulfonate: An alternative to pentafluorophenyl (PFP) and trichlorophenyl (TCP) esters of sulfonic acids

The N-hydroxybenzotriazole (HOBt) sulfonate esters undergo amidation under ambient conditions in the presence of di-isopropylethyl amine. This method can be applied to varieties of amines including sterically hindered amino acid esters in less time with reasonably good yields. HOBt ester of sulfonic acids can be a replacement for pentafluorophenyl and trichlorophenyl ester as well as chloride moiety of sulfonyl chloride for amidation.