859963-94-3Relevant articles and documents
Palladium-Catalyzed Enantioselective C-H Aminocarbonylation: Synthesis of Chiral Isoquinolinones
Han, Hui,Zhang, Tao,Yang, Shang-Dong,Lan, Yu,Xia, Ji-Bao
supporting information, p. 1749 - 1754 (2019/03/11)
A Pd-catalyzed enantioselective C-H carbonylation by desymmetrization was developed with commercially available L-pyroglutamic acid as chiral ligand. Isoquinolinones were successfully obtained with good yields and high enantioselectivities. Mechanistic studies and DFT calculations provided a reasonable reaction pathway.