860020-54-8

Basic information

• Product Name: N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl
• Synonyms: N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl
• CAS NO: 860020-54-8
• Molecular Weight: 1195.38
• Mol File: 860020-54-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl(860020-54-8)
• EPA Substance Registry System: N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl(860020-54-8)

Safety Data

• Hazardous Substances Data: 860020-54-8(Hazardous Substances Data)

Upstream product

• 145757-48-8 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetic acid 
• 114856-02-9 Boc-Ala-Lys(Z)-OBzl 
• 77236-13-6 N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester 
• 38577-52-5 1,3-dihydroxyl-2-(4'-hydroxyphen-1'-yl)-4,4,5,5-tetramethylimidazolidine 
• 642097-77-6 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetic ethyl ester 
• 544477-17-0 Boc-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202411-01-6 Boc-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202410-99-9 Boc-Pro-Ala-Lys(Z)-OBzl 
• 100-39-0 benzyl bromide 
• 6366-70-7 N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride 
• 14384-45-3 N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine 
• 2389-45-9 Boc-Lys(Z)-OH 
• 3964-18-9 2,3-dimethyl-2,3-dinitrobutane 
• 38582-75-1 2-(4-hydroxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-3-oxido-3-imidazolio-1-oxyl 

Relevant articles and documents

Synthesis and biological activity of nitronyl nitroxide containing peptides

[1-(1′,3′-Dioxyl-4′,4′,5′, 5′-tetramethyldihydroimidazol-2-yl)-phenyl-4-yl]oxyacetic acid (4), a nitronyl nitroxide, and its peptide derivatives, N-[1-(1′,3′-dioxyl- 4′,4′,5′,5′-tetramethyldihydroimidazol-2-yl) -phenyl-4-yl]oxyacetyl-ARPAK (9a), -GRPAK (9b), and -QRPAK (9c), were synthesized and characterized. Judging from the results of electron spin resonance analysis, the newly synthesized nitronyl nitroxide containing peptides, 9a, 9b, and 9c, demonstrated the characteristics of free radicals. The free radical scavenging activities of 9a, 9b, and 9c were assessed using in vitro free radical scavenging tests. The thrombolysis effect of 9a, 9b, and 9c was evaluated using an euglobulin clot lysis test, a fibrinolytic lysis test, and in vivo thrombolysis tests. Results indicated that these nitronyl nitroxide containing peptides possessed both free radical scavenging activity and thrombolytic activity.