86046-98-2

Upstream product

• 80925-23-1 (2S,3S,4R)-(-)-5-benzyloxy-2,3-epoxy-2,4-dimethylpentanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 63930-46-1 (S)-3-benzyloxy-2-methylpropan-1-ol 
• 79026-61-2 (R)-3-benzyloxy-2-methylpropanal 
• 100-39-0 benzyl bromide 
• 80925-22-0 (R)-(+)-5-benzyloxy-2,4-dimethyl-(E)-2-pentenol 
• 80885-47-8 (R)-(+)-5-benzyloxy-2,4-dimethyl-(E)-2-pentenal 
• 86046-97-1 (2R)-(-)-benzyl 3-(1'-ethoxyethoxy)-2-methylpropyl ether 
• 86046-97-1 [(R)-3-(1-Ethoxy-ethoxy)-2-methyl-propoxymethyl]-benzene 

Downstream Products

• 86117-47-7 [({2-Chloro-5-[(2E,4E)-(6R,9S,10R)-9-(1-ethoxy-ethoxy)-7,7-bis-ethylsulfanyl-10-((2S,3R)-3-formyl-3-methyl-oxiranyl)-6-methoxy-2-methyl-undeca-2,4-dienyl]-3-methoxy-phenyl}-methyl-carbamoyl)-methyl]-phosphonic acid diethyl ester 
• 86116-97-4 C₄₅H₈₀ClNO₈S₂Si₂ 
• 86046-99-3 C₄₄H₇₈ClNO₈S₂Si₂ 
• 86046-99-3 C₄₄H₇₈ClNO₈S₂Si₂ 
• 52978-28-6 (-)-maysine 
• 72729-16-9 {(2S,3S)-3-[(6E,8E)-(1R,2S,5R)-10-(4-Chloro-3-methoxy-5-methylamino-phenyl)-2-(1-ethoxy-ethoxy)-4,4-bis-ethylsulfanyl-5-methoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol 
• 86117-46-6 (2R,3S)-3-[(6E,8E)-(1R,2S,5R)-10-(4-Chloro-3-methoxy-5-methylamino-phenyl)-2-(1-ethoxy-ethoxy)-4,4-bis-ethylsulfanyl-5-methoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxirane-2-carbaldehyde 

Relevant academic research and scientific papers

Total synthesis of (-)-maysine

A convergent synthesis of the natural macrocycle (-)-maysine (3) has been accomplished involving only a single separation of epimers at C-10. The scheme involved the preparation of three major fragments: (a) the western zone, 4; (b) the southern zone, 6;

ENANTIOSELECTIVE SYNTHESIS OF C3-C10 FRAGMENT (NORTHEASTERN ZONE) OF MAYTANSINOIDS WITH 4-CHIRAL CENTERS (4S,5S,6R,7S)

The major precursor to the maytansinoids containing 4 non-racemic chiral centers has been prepared in gram quantities, suitable for further synthesis.The route to (+)-1 was accomplished in 13 steps including several highly stereocontrolled reactions which