86052-27-9

Upstream product

• 50917-72-1 aminomethylphosphonic acid diethyl ester 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 86052-38-2 1-(2-chlorophenyl)-4-(thien-2-yl)-4-methyl-2-azabuta-1,3-diene 
• 86052-28-0 1-(2-chlorophenyl)-4-(thienyl-2)-2-azabuta-1,3-diene 
• 86052-28-0 1-(2-chlorophenyl)-4-(thien-2-yl)-2-azabuta-1,3-diene 
• 69061-17-2 N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine 
• 86052-58-6 N-(2-chlorobenzyl)-2-(thien-2-yl)-2-methyl-ethylamine 
• 86423-60-1 Diethyl N-(2-o-chlorophenylethyl)phosphoramidate 
• 13078-80-3 2-(2-chlorophenyl)ethanamine 
• 86423-59-8 Diethyl N-<β-(o-chlorophenyl)-vinyl>phosphoramidate 

Relevant academic research and scientific papers

REACTION DE WITTIG-HORNER et TRANSFORMATION DES ALDEHYDES ET CETONES EN AMINES SUPERIEURES I. UN NOUVEAU REARRANGEMENT: IMINOPHOSPHONATES-PHOSPHORAMIDATES; MISE EN EVIDENCE ET ETUDE

The rearrangement in basic medium of A, (X,Y)P(O)-C(R)H-N=CH-, into B, (X,Y)P(O)-NH-C(R)=CH- is described for the first time.This transformation, sensitive to temperature, requires that R is hydrogen and that among X and Y one has to be an alkoxy group.For the rearrangement A-->B a mechanism is proposed which is analogous to the transformation of C, (X,Y)P(O)-C-NH-, into D, (X,Y)P(O)-N-C-H, described previously.

PO-Activated Olefination and Conversion of Aldehydes and Ketones to Higher Amines; II. Synthesis of Arylethylamines

The transformation of arylcarboxaldehydes and/or - ketones 2 by three different routes into arylethylamines 3 and/or 4 is reported.According to the first route, the intermediate iminophosphonates 9 react through a classical PO-activated olefination.The second and the third involve the rearrangement of the iminophosphonates 9 into the vinylphosphoramidates 12.

Process for the preparation of β-cyclo-substituted ethylamines

The present invention provides a multistep process for the preparation of β-cyclo-substituted ethylamines of the general formula:- in which AR is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or poly- substituted, wherein said compounds represent a class of intermediates which can be converted to 4,5,6,7-tetrahydro[3,2-C] or [2,3-C]pyridines wherein the latter are useful for anti-inflammatory, vasodilator or blood platelet aggregation inhibition activities.

Process for the preparation of 2-(thien-2-yl)- and 2-(thien-3-yl)-ethylamine derivatives

The present invention provides a process for the preparation of 2-(thien-2-yl)- and 2-(thien-3-yl)-ethylamine derivatives of the general formula: STR1 in which R1, in the 2-, 3-, 4- or 5-position, is a hydrogen or halogen atom, a nitro, carboxyl, cyano or amino group, a linear or branched alkyl or alkoxy radical or a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or polysubstituted, the aminoethyl chain is in the 2- or 3-position, R2, R3 and R4, which are the same or different, are hydrogen atoms or heterocyclic or non-heterocyclic aromatic radicals, which are optionally mono- or polysubstituted, and Ar is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or polysubstituted.