69061-17-2

Basic information

• Product Name: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE
• Synonyms: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE;N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HCL;N-[(2-chlorophenyl)methyl]thiophene-3-ethylamine;2-CHLOROBENZYLAMINE-1(THIENYL-2)-2-ETHANE HCL;N-[(2-Chlorophenyl)methyl]-2-thiopheneethanamine;Ticlopidine IMpurity I
• CAS NO: 69061-17-2
• Molecular Formula: C₁₃H₁₄ClNS
• Molecular Weight: 288.24
• EINECS: 273-851-0
• Mol File: 69061-17-2.mol

Chemical Properties

• Boiling Point: 362.9 °C at 760 mmHg
• Flash Point: 173.3 °C
• Appearance: /
• Density: 1.201 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(69061-17-2)
• EPA Substance Registry System: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(69061-17-2)

Safety Data

• Hazardous Substances Data: 69061-17-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H14ClNS/c14-13-4-2-1-3-12(13)9-15-7-5-11-6-8-16-10-11/h1-4,6,8,10,15H,5,7,9H2

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 86052-27-9 N-orthochlorobenzylidene-aminomethylphosphonate de diethyle 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 122853-32-1 C₁₃H₁₂ClNS 
• 20893-30-5 2-cyanomethylthiophene 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 2786-07-4 2-thienyl lithium 
• 143810-09-7 N-(2-chlorobenzyl)-2,2-dioxo-1,2,3-oxathiazolidine 
• 86052-27-9 Diethyl N-o-chlorobenzylideneaminomethylphosphonate 
• 86052-31-5 Diethyl N-2-thienylideneaminomethylphosphonate 
• 98-03-3 thiophene-2-carbaldehyde 
• 86052-28-0 1-(2-chlorophenyl)-4-(thienyl-2)-2-azabuta-1,3-diene 
• 86052-28-0 1-(2-chlorophenyl)-4-(thien-2-yl)-2-azabuta-1,3-diene 

Downstream Products

• 53885-35-1 ticlopidine hydrochloride 
• 90055-48-4 clopidogrel 
• 141109-26-4 2-(2-thiophen-2-yl ethylamino)(2-chlorophenyl)acetic acid methyl ester 
• 102997-10-4 6-(2-chlorobenzyl)-4-hydroxy-5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine 
• 102997-06-8 6-(2-chlorobenzyl)-5,6,7,8-tetrahydrothieno<2,3-d>azepin-4-one 
• 102997-16-0 6-(2-chlorobenzyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine 
• 102997-03-5 N,N-(chloroacetyl)(2-chlorobenzyl)-2-(2-thienyl)ethylamine 

Relevant articles and documents

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PO-Activated Olefination and Conversion of Aldehydes and Ketones to Higher Amines; II. Synthesis of Arylethylamines

The transformation of arylcarboxaldehydes and/or - ketones 2 by three different routes into arylethylamines 3 and/or 4 is reported.According to the first route, the intermediate iminophosphonates 9 react through a classical PO-activated olefination.The second and the third involve the rearrangement of the iminophosphonates 9 into the vinylphosphoramidates 12.

REACTION DE WITTIG-HORNER et TRANSFORMATION DES ALDEHYDES ET CETONES EN AMINES SUPERIEURES I. UN NOUVEAU REARRANGEMENT: IMINOPHOSPHONATES-PHOSPHORAMIDATES; MISE EN EVIDENCE ET ETUDE

The rearrangement in basic medium of A, (X,Y)P(O)-C(R)H-N=CH-, into B, (X,Y)P(O)-NH-C(R)=CH- is described for the first time.This transformation, sensitive to temperature, requires that R is hydrogen and that among X and Y one has to be an alkoxy group.For the rearrangement A-->B a mechanism is proposed which is analogous to the transformation of C, (X,Y)P(O)-C-NH-, into D, (X,Y)P(O)-N-C-H, described previously.

Process for the preparation of 2-(thien-2-yl)- and 2-(thien-3-yl)-ethylamine derivatives

The present invention provides a process for the preparation of 2-(thien-2-yl)- and 2-(thien-3-yl)-ethylamine derivatives of the general formula: STR1 in which R1, in the 2-, 3-, 4- or 5-position, is a hydrogen or halogen atom, a nitro, carboxyl, cyano or amino group, a linear or branched alkyl or alkoxy radical or a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or polysubstituted, the aminoethyl chain is in the 2- or 3-position, R2, R3 and R4, which are the same or different, are hydrogen atoms or heterocyclic or non-heterocyclic aromatic radicals, which are optionally mono- or polysubstituted, and Ar is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or polysubstituted.