860624-91-5

Basic information

• Product Name: 5-broMo-1H-indole-7-carboxaMide
• Synonyms: 5-broMo-1H-indole-7-carboxaMide
• CAS NO: 860624-91-5
• Molecular Formula: C₉H₇BrN₂O
• Molecular Weight: 239.06868
• EINECS: -0
• Mol File: 860624-91-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-broMo-1H-indole-7-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-1H-indole-7-carboxaMide(860624-91-5)
• EPA Substance Registry System: 5-broMo-1H-indole-7-carboxaMide(860624-91-5)

Safety Data

• Hazardous Substances Data: 860624-91-5(Hazardous Substances Data)

Usage

Description

5-Bromo-1H-indole-7-carboxamide is a chemical compound with the molecular formula C9H8BrN2O. It is a derivative of indole, a heterocyclic aromatic organic compound, characterized by the presence of a bromine atom and an amide functional group. Its chemical properties and structure make it suitable for applications in medicinal chemistry and drug discovery.

Uses

Used in Organic Synthesis:
5-Bromo-1H-indole-7-carboxamide is used as a building block in organic synthesis for the preparation of various compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, 5-bromo-1H-indole-7-carboxamide is used as a lead compound for the development of new pharmaceutical products.
Used as a Research Tool:
5-Bromo-1H-indole-7-carboxamide may also have use as a research tool in the investigation of biological processes and pharmaceutical targets.

Upstream product

• 1065181-58-9 ethyl 5-bromo-1H-indole-7-carboxylate 
• 1065181-56-7 ethyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate 
• 1065181-52-3 1-(1,1-dimethylethyl) 7-ethyl 2,3-dihydro-1H-indole-1,7-dicarboxylate 
• 143262-10-6 1-(tert-butoxycarbonyl)indoline 
• 860624-89-1 methyl 5-bromo-1H-indole-7-carboxylate 
• 860624-88-0 methyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate 
• 860624-87-9 1-(1,1-dimethylethyl) 7-methyl 5-bromo-2,3-dihydro-1H-indole-1,7-dicarboxylate 
• 496-15-1 1-indoline 
• 860624-90-4 5-bromo-1H-indole-7-carboxylic acid 
• 197460-40-5 1-(1,1-dimethylethyl) 7-methyl 2,3-dihydro-1H-indole-1,7-dicarboxylate 

Downstream Products

• 860625-18-9 1,1-dimethylethyl-4-[7-(aminocarbonyl)-5-bromo-1H-indol-3-yl]-1-piperidine carboxylate 
• 860626-15-9 5-phenyl-3-[1-(phenylmethyl)-1,2,3,6-tetrahydro-4-pyridinyl]-1H-indole-7-carboxamide 
• 860626-16-0 5-phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamide 
• 881380-90-1 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide 

Relevant articles and documents

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity. In doing so

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

CHEMICAL COMPOUNDS

The invention is directed to novel indolecarboxamide derivatives, Specifically, the invention is directed to compounds according to formula (I), where R1 , R2, R3 and X are defined below. These compounds are useful in the treatment of disorders associated