86147-93-5Relevant academic research and scientific papers
Racemase activity of B. cepacia lipase leads to dual-function asymmetric dynamic kinetic resolution of α-aminonitriles
Vongvilai, Pornrapee,Linder, Mats,Sakulsombat, Morakot,Svedendahl Humble, Maria,Berglund, Per,Brinck, Tore,Ramstroem, Olof
supporting information; experimental part, p. 6592 - 6595 (2011/09/15)
Applaudable promiscuity: Racemase-type activity discovered for B. cepacia lipase with N-substituted α-aminonitriles is proposed to involve a C-C bond-breaking/forming mechanism in the hydrolase site of the enzyme, as supported by experimental data and calculations. This promiscuous activity in combination with the transacylation activity of the enzyme enabled the asymmetric synthesis of N-methyl α-aminonitrile amides in high yield (see scheme). Copyright
Design, synthesis and antioxidant properties of ovothiol-derived 4-mercaptoimidazoles
Zoete, Vincent,Bailly, Fabrice,Catteau, Jean-Pierre,Bernier, Jean-Luc
, p. 2983 - 2988 (2007/10/03)
Fourteen 4-mercaptoimidazoles derived from the naturally occurring family of antioxidants, the ovothiols, have been synthesized by cyclization of thioamides with trimethylsilyl trifluoromethane-sulfonate (triflate). These compounds have been assayed for their radical-scavenging activity.
Studies on Mesoionic Compounds. Part 10. Synthesis and Chemical Properties of Mesoionic 1,2,5-Thiadiazolium-3-olates
Masuda, Katsutada,Adachi, Jun,Nomura, Keiichi
, p. 1033 - 1036 (2007/10/02)
The preparation of a novel mesoionic heterocycle is described; derivatives of 4-aryl-5-alkyl-1,2,5-thiadiazolium-3-olates (6a-f) are obtained by treatment of α-N-substituted aminophenylacetamides with sulphur monochloride followed by base.
