1-bromo-3-iodo-5-nitrobenzene

Base Information

• Chemical Name: 1-bromo-3-iodo-5-nitrobenzene
• CAS No.: 861601-15-2
• Molecular Formula: C6H3BrINO2
• Molecular Weight: 327.904
• Hs Code.: 2904990090
• Mol file: 861601-15-2.mol

Synonyms:1-bromo-3-iodo-5-nitrobenzene;3-Bromo-5-iodonitrobenzene;3-Bromo-5-nitroiodobenzene;Benzene,1-broMo-3-iodo-5-nitro-;3-Bromo-5-iodonitrobenzene 95%

Chemical Property of 1-bromo-3-iodo-5-nitrobenzene

Chemical Property:

• PSA: 45.82000
• LogP: 3.48510
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-iodonitrobenzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-bromo-3-iodo-5-nitrobenzene

There total 6 articles about 1-bromo-3-iodo-5-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-bromo-2-nitro-6-iodoaniline (180624-08-2) → 1-bromo-3-iodo-5-nitrobenzene (861601-15-2)

Guidance literature:

4-bromo-2-nitro-6-iodoaniline; With sulfuric acid; at 0 - 5 ℃; for 1h;

With sodium nitrite; at 0 - 5 ℃; for 2h;

With ethanol; copper(II) sulfate; In water; for 2h; Heating / reflux;

Reference yield: 81.0%

4-bromo-2-nitrobenzoic acid (99277-71-1) → 1-bromo-3-iodo-5-nitrobenzene (861601-15-2)

Guidance literature:

With copper(I) oxide; potassium phosphate; bismuth (III) nitrate pentahydrate; palladium(II) trifluoroacetate; oxygen; sodium iodide; In dimethyl sulfoxide; at 170 ℃; for 10h; regioselective reaction; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.9b00460

Reference yield:

4-Bromo-2-nitroaniline (875-51-4) → 1-bromo-3-iodo-5-nitrobenzene (861601-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid dichloroamide; glacial acetic acid; sodium iodide

2: pentyl nitrite; alcohol

With N,N-dichloro-p-toluenesulfonamide; n-Amyl nitrite; ethanol; acetic acid; sodium iodide;

upstream raw materials:

2-Brom-6-iod-4-nitroanilin

4-bromo-2-nitro-6-iodoaniline

4-Bromo-2-nitroaniline

2-bromo-4-nitroaniline

Downstream raw materials:

3-Bromo-5-iodoaniline

1-benzoyl-3-(3-bromo-5-iodophenyl)thiourea

(3-bromo-5-iodophenyl)thiourea