861821-64-9Relevant academic research and scientific papers
NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy
Wang, Yan-Bing,Shi, Linlin,Zhang, Xiaojie,Fu, Lian-Rong,Hu, Weinan,Zhang, Wenjing,Zhu, Xinju,Hao, Xin-Qi,Song, Mao-Ping
, p. 947 - 958 (2021/01/14)
A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.
Sequentially Pd/Cu-Catalyzed Alkynylation-Oxidation Synthesis of 1,2-Diketones and Consecutive One-Pot Generation of Quinoxalines
Niesobski, Patrik,Martínez, Ivette Santana,Kustosz, Sebastian,Müller, Thomas J. J.
, p. 5214 - 5218 (2019/07/31)
We report a simple and efficient one-pot synthesis of 1,2-diketones by concatenation of two Pd/Cu-catalyzed processes: Pd0/CuI-catalyzed Sonogashira coupling of terminal alkynes with aryl (pseudo)halides furnishes internal alkynes, which are directly transformed by PdII/CuII-catalyzed Wacker-type oxidation with DMSO and oxygen as dual oxidants to furnish 1,2-diketones. With this efficient, catalyst economical process, various aryl iodides and triflates are efficiently transformed in high yields into symmetrically and unsymmetrically substituted 1,2-diketones with various functional groups. This process can be readily extended to a consecutive one-pot synthesis of quinoxalines in a diversity-oriented fashion.
Synthesis of quinoxalines by a carbon nanotube-gold nanohybrid-catalyzed cascade reaction of vicinal diols and keto alcohols with diamines
Shah, Nimesh,Gravel, Edmond,Jawale, Dhanaji V.,Doris, Eric,Namboothiri, Irishi N. N.
, p. 57 - 61 (2015/03/05)
A one-pot oxidation-condensation method for the synthesis of quinoxalines from readily available benzoins or benzhydrols and 1,2-phenylenediamines or 2,3-diaminopyridine by use of a gold-carbon nanotube nanohybrid as a heterogeneous catalyst is reported. Quinoxalines are formed under mild conditions in air and in excellent yields. The simple and efficient methodology offers a safe and sustainable alternative to conventional acid and/or base-catalyzed thermal processes.
Niobium pentachloride as a highly efficient catalyst for the synthesis of quinoxaline derivatives
Kidwai, Mazaahir,Mishra, Neeraj Kumar,Bhatnagar, Divya,Jahan, Anwar
experimental part, p. 5051 - 5054 (2012/07/03)
Niobium pentachloride is found to be an efficient catalyst for the synthesis of quinoxaline derivatives via the condensation of aromatic 1,2-dicarbonyl compounds (or unsymmetrical 1,2-diketones or α-hydroxy ketones) with 1,2-diamines. All the reactions were performed at room temperature while using acetonitrile as solvent. The present methodology offers several advantages such as excellent yields, short reaction time and environmentally benign milder reaction conditions.
