862414-82-2 Usage
Uses
Used in Pharmaceutical Industry:
(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester is used as a key intermediate in the synthesis of rhinovirus protease inhibitors. These inhibitors are designed to target and inhibit the activity of rhinovirus proteases, which are essential for the replication and pathogenesis of the virus. By inhibiting the protease, the compound can potentially help in the treatment and prevention of rhinovirus infections, which are a major cause of the common cold.
Additionally, (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester is also used in the preparation of peptidomimetic α,β-unsaturated esters. These esters are structural analogs of natural peptides, designed to mimic their biological activity while offering improved stability and pharmacokinetic properties. Peptidomimetics have a wide range of applications in the pharmaceutical industry, including the development of drugs for various therapeutic areas such as oncology, infectious diseases, and central nervous system disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 862414-82-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,2,4,1 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 862414-82:
(8*8)+(7*6)+(6*2)+(5*4)+(4*1)+(3*4)+(2*8)+(1*2)=172
172 % 10 = 2
So 862414-82-2 is a valid CAS Registry Number.
862414-82-2Relevant academic research and scientific papers
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
Shie, Jiun-Jie,Fang, Jim-Min,Kuo, Tun-Hsun,Kuo, Chih-Jung,Liang, Po-Huang,Huang, Hung-Jyun,Wu, Yin-Ta,Jan, Jia-Tsrong,Cheng, Yih-Shyun E.,Wong, Chi-Huey
, p. 5240 - 5252 (2007/10/03)
The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide α,β-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease. Though AG7088 is inactive (IC50 > 100 μM), the ketomethylene isosteres and tripeptide α,β-unsaturated esters containing both P1 and P2 phenylalanine residues show modest inhibitory activity (IC50 = 11-39 μM). The Phe-Phe dipeptide inhibitors 18a-e are designed on the basis of computer modeling of the enzyme-inhibitor complex. The most potent inhibitor 18c with an inhibition constant of 0.52 μM is obtained by condensation of the Phe-Phe dipeptide α,β-unsaturated ester with 4-(dimethylamino)cinnamic acid. The cell-based assays also indicate that 18c is a nontoxic anti-SARS agent with an EC50 value of 0.18 μM.
