(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester

Base Information

Chemical Name:(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester
CAS No.:862414-82-2
Molecular Formula:C₂₃H₃₂FNO₅
Molecular Weight:421.509
Hs Code.:
Mol file:862414-82-2.mol

Synonyms:allyl (2R,5S)-5-(tert-butoxycarbonyl)amino-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Suppliers and Price of (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Medical Isotopes, Inc.
(αR)-α-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid2-Propen-1-ylEster
2.5 mg
$ 650.00

TRC
(αR)-α-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid2-Propen-1-ylEster
2.5mg
$ 165.00

Total 0 raw suppliers

Chemical Property of (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester

Chemical Property:

Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:: (αR)-α-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid2-Propen-1-ylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester is used in the preparation of rhinovirus protease inhibitors and peptidomimetic α,β-unsaturated esters.

Technology Process of (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester

There total 8 articles about (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 556-56-9
allyl iodid

: 223526-67-8
(2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanic acid

: 862414-82-2
allyl (2R,5S)-5-(tert-butoxycarbonyl)amino-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 45 ℃; for 5h;
DOI:10.1016/j.bmc.2005.05.065

Reference yield:

: 124980-98-9
(R)-methyl 3-(4-fluorophenyl)-2-hydroxypropanoate

: 862414-82-2
allyl (2R,5S)-5-(tert-butoxycarbonyl)amino-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.67 h / 0 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: tetrahydrofuran / 24 h / 0 - 20 °C

3.1: CF₃CO₂H / CH₂Cl₂ / 24 h / 20 °C

4.1: 83 percent / H₂ / Pd-C / methanol / 10 h / 20 °C

5.1: 90 percent / lithium hydroxide / H₂O; methanol / 1 h / 0 °C

6.1: 84 percent / Cs₂CO₃ / dimethylformamide / 5 h / 45 °C

With 2,6-dimethylpyridine; lithium hydroxide; hydrogen; sodium hydride; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.05.065

Reference yield:

: 328273-04-7
(2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

: 862414-82-2
allyl (2R,5S)-5-(tert-butoxycarbonyl)amino-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: tetrahydrofuran / 24 h / 0 - 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 24 h / 20 °C

3.1: 83 percent / H₂ / Pd-C / methanol / 10 h / 20 °C

4.1: 90 percent / lithium hydroxide / H₂O; methanol / 1 h / 0 °C

5.1: 84 percent / Cs₂CO₃ / dimethylformamide / 5 h / 45 °C

With lithium hydroxide; hydrogen; sodium hydride; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.05.065