86244-66-8Relevant academic research and scientific papers
Process for the monoalkylation of C-H acid methylene groups
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Page/Page column 5 - 6, (2008/06/13)
The ratio of the alkali(ne earth) carbonate to the methylene group-containing substrate is above 0.6 : 1 in the monoalkylation of C-H acid methylene groups by reaction of the substrate in a polar aprotic solvent with a dihalogen compound having its halogens separated by a chain of at least3C and with reaction being in presence of the alkali(ne earth) carbonates and a phase transfer catalyst and being accompanied by continuous removal of the water formed. An Independent claim is also included for production of omega-haloalkyl-nitriles or -carboxylic acids by reacting a malonic acid diester or cyanoacetic ester with an alpha,omega-dihaloalkane as above and then saponifying and decarboxylating the product.
Acides gras marques en position ω par un nucleide radioactif emetteur γ
Riche, Francoise,Mathieu, Jean-Paul,Vincens, Maurice,Bardy, Andre,Comet, Michel,Vidal, Michel
, p. 49 - 55 (2007/10/02)
The synthesis of many saturated, acetylenic, olefinic (Z or E) fatty acids labeled with 123I or 131I at the ω-position has been achieved.The radioactive iodine atom is introduced by a I-, *I- exchange reaction; the influence on the yield of several parameters - presence of iodine carrier, fatty acid and water concentrations, solution acidity - has been studied.Experimental conditions which produce labeling yields higher than 95percent have been defined; these results have lead to a very easy labeling method used in several hospitals in the external study of myocardial metabolism of fatty acids.
