862854-00-0Relevant academic research and scientific papers
Synthesis and biological evaluation of novel pyridazinone-based α4 integrin receptor antagonists
Gong, Yong,Barbay, J. Kent,Dyatkin, Alexey B.,Miskowski, Tamara A.,Kimball, Edward S.,Prouty, Stephen M.,Fisher, M. Carolyn,Santulli, Rosemary J.,Schneider, Craig R.,Wallace, Nathaniel H.,Ballentine, Scott A.,Hageman, William E.,Masucci, John A.,Maryanoff, Bruce E.,Damiano, Bruce P.,Andrade-Gordon, Patricia,Hlasta, Dennis J.,Hornby, Pamela J.,He, Wei
, p. 3402 - 3411 (2007/10/03)
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by α4β1/VCAM-1 and α4β 7MAdCAM-1 interactions. Concise syntheses were
PYRIDAZINONE UREAS AS ANTAGONISTS OF α4 INTEGRINS
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Page/Page column 64-65, (2010/02/13)
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating α4 integrin mediated disorders. More particularly, the pyridazinone urea compounds of th
