862854-54-4

Upstream product

• 862854-58-8 (S)-2-amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid 
• 67-56-1 methanol 
• 862854-59-9 (S)-2-amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid trifluoroacetic acid salt 

Downstream Products

• 863228-06-2 (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester 
• 863228-88-0 C₂₆H₃₆N₄O₇ 
• 862854-00-0 (S)-2-(3-Isobutyl-3-methyl-ureido)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid 

Relevant academic research and scientific papers

Synthesis and SAR of pyridazinone-substituted phenylalanine amide α4 integrin antagonists

Structural modification and cellular adhesion inhibition activities of pyridazinone-substituted phenylalanine amide α4 integrin antagonists are described. Functionality requirements for the arylamide moiety and the carboxylic acid group were de

BICYCLIC TRIAZOLE A4 INTEGRIN INHIBITORS

The compounds of the present invention are novel bicyclic triazole amino acid-derivatives useful as a4 integrin receptor antagonists. The invention is further directed to methods for treating integrin mediated disorders including, but not limited to, infl

Pyridazinones as antagonists of alpha4 integrins

The present invention relates to certain novel compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of integrin mediated disorders.

PYRIDAZINONE UREAS AS ANTAGONISTS OF α4 INTEGRINS

The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating α4 integrin mediated disorders. More particularly, the pyridazinone urea compounds of th