862876-04-8

Basic information

• Product Name: N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide
• Synonyms: N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide
• CAS NO: 862876-04-8
• Molecular Weight: 273.762
• Mol File: 862876-04-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide(862876-04-8)
• EPA Substance Registry System: N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide(862876-04-8)

Safety Data

• Hazardous Substances Data: 862876-04-8(Hazardous Substances Data)

Upstream product

• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 
• 98-86-2 acetophenone 
• 201230-82-2 carbon monoxide 
• 20265-96-7 p-chloroaniline hydrochloride 
• 98-83-9 isopropenylbenzene 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 106-47-8 4-chloro-aniline 
• 4750-28-1 N-(4-chlorophenyl)benzenesulfonamide 
• 89372-28-1 1-(2-methyl-2-phenylpropanoyl)-1H-imidazole 

Relevant articles and documents

Palladium-Catalyzed Markovnikov Hydroaminocarbonylation of 1,1-Disubstituted and 1,1,2-Trisubstituted Alkenes for Formation of Amides with Quaternary Carbon

Hydroaminocarbonylation of alkenes is one of the most promising yet challenging methods for the synthesis of amides. Herein, we reported the development of a novel and effective Pd-catalyzed Markovnikov hydroaminocarbonylation of 1,1-disubstituted or 1,1,2-trisubstituted alkenes with aniline hydrochloride salts to afford amides bearing an α quaternary carbon. The reaction makes use of readily available starting materials, tolerates a wide range of functional groups, and provides a facile and straightforward approach to a diverse array of amides bearing an α quaternary carbon. Mechanistic investigations suggested that the reaction proceeded through a palladium hydride pathway. The hydropalladation and CO insertion are reversible, and the aminolysis is probably the rate-limiting step.

Visible Light-Induced Radical Rearrangement to Construct C-C Bonds via an Intramolecular Aryl Migration/Desulfonylation Process

A highly efficient intramolecular selective aryl migration/desulfonylation of 2-bromo-N-aryl-N-(arenesulfonyl)amide via visible light-induced photoredox catalysis has been accomplished. This approach allows for the construction of a variety of multisubstituted N,2-diarylacetamide under mild reaction conditions.

A comparison of catalysts to promote imidazolide couplings including the identification of 2-hydroxy-5-nitropyridine as a new, safe, and effective catalyst

Five catalysts were compared with respect to their safety and catalytic effectiveness for promoting imidazolide couplings. Reaction rate enhancement, shock sensitivity, and differential scanning calorimetry (DSC) data were considered in this analysis. 6-Chloro-1-hydroxybenzotriazole, which has been described in the literature as a safe catalyst, was found to be shock sensitive. 2-Hydroxy-5-nitropyridine is a new catalyst for this type of reaction and was found to be safe, effective, readily available, and similar in price to that of the 1-hydroxybenzotriazole, a common catalyst for promoting acylation reactions.