863226-76-0Relevant articles and documents
Synthesis and SAR of pyridazinone-substituted phenylalanine amide α4 integrin antagonists
Gong, Yong,Kent Barbay,Kimball, Edward S.,Santulli, Rosemary J.,Carolyn Fisher,Dyatkin, Alexey B.,Miskowski, Tamara A.,Hornby, Pamela J.,He, Wei
, p. 1331 - 1335 (2008/09/19)
Structural modification and cellular adhesion inhibition activities of pyridazinone-substituted phenylalanine amide α4 integrin antagonists are described. Functionality requirements for the arylamide moiety and the carboxylic acid group were de
Synthesis and biological evaluation of novel pyridazinone-based α4 integrin receptor antagonists
Gong, Yong,Barbay, J. Kent,Dyatkin, Alexey B.,Miskowski, Tamara A.,Kimball, Edward S.,Prouty, Stephen M.,Fisher, M. Carolyn,Santulli, Rosemary J.,Schneider, Craig R.,Wallace, Nathaniel H.,Ballentine, Scott A.,Hageman, William E.,Masucci, John A.,Maryanoff, Bruce E.,Damiano, Bruce P.,Andrade-Gordon, Patricia,Hlasta, Dennis J.,Hornby, Pamela J.,He, Wei
, p. 3402 - 3411 (2007/10/03)
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by α4β1/VCAM-1 and α4β 7MAdCAM-1 interactions. Concise syntheses were
Pyridazinones as antagonists of alpha4 integrins
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Page/Page column 28, (2010/02/13)
The present invention relates to certain novel compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of integrin mediated disorders.
