Organic Process Research and Development p. 899 - 902 (2007)
Update date:2022-07-29
Topics:
Boros, Eric E.
Burova, Svetlana A.
Erickson, Greg A.
Johns, Brian A.
Koble, Cecilia S.
Kurose, Noriyuki
Sharp, Matthew J.
Tabet, Elie A.
Thompson, James B.
Toczko, Matthew A.
A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2- pyridinecarboxylate (1b), starting from 5-bromo-2-methoxypyridine (8) and 4-fluorobenzaldehyde (9), is described. Key steps in the process include lithium-bromine exchange of 8, addition of the
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Doi:10.1016/0008-6215(85)85194-6
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(2005)
