Design and Synthesis of Conformationally Constrained Somatostatin Analogues with High Potency and Specificity for μ Opioid Receptors

DOI: 10.1021/jm00161a037

Source and publish data:

Journal of Medicinal Chemistry p. 2370 - 2375 (1986)

Update date:2022-08-03

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Authors:

Pelton, John T.

Kazmierski, Wieslaw

Gulya, Karoly

Yamamura, Henry I.

Hruby, Victor J.

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Article abstract of DOI:10.1021/jm00161a037

A series of cyclic, conformationally constrained peptides related to somatostatin were designed and synthesized in an effort to develop highly selective and potent peptides for the μ opioid receptor.The following new peptides were prepared and tested for

Full text of DOI:10.1021/jm00161a037

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