863453-76-3

Usage

Physical state

Yellow to orange solid

Molecular weight

206.24 g/mol

Classification

Organic compound

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Potential hazards

Potentially hazardous chemical, should be handled with care

Reactant in production

Pharmaceutical drugs and agrochemicals formulation

Upstream product

• 123-75-1 pyrrolidine 
• 5198-52-7 3-(4-nitrophenyl)-2-oxazolidinone 
• 7154-73-6 1-(2-aminoethyl)pyrrolidine 
• 350-46-9 4-Fluoronitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 1965-54-4 N-(2-hydroxyethyl)-4-nitroaniline 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 863453-84-3 N-(2-pyrrolidin-1-ylethyl)benzene-1,4-diamine 

Relevant academic research and scientific papers

Short and practical synthesis of N′,N′-disubstituted N-aryl-1,2-ethylene-diamines by a decarboxylative ring-opening reaction under nucleophilic conditions

A straightforward and practical synthesis of N′,N′- disubstituted N-aryl-1,2-ethylenediamines, starting from anilines, via N-aryloxazolidin-2-ones is described. A decarboxylative ring-opening reaction of N-aryloxazolidin-2-ones, using aliphatic secondary

Kinase Inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

N-alkylamino secondary para-phenylenediamine, composition for dyeing keratin fibers comprising such a para-phenylenediamine, processes using this composition and uses thereof

The present disclosure relates to novel N-alkylamino secondary para-phenylenediamines; a composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising, in a medium suitable for dyeing, at least one such N-alkylamino secondary para-phenylenediamine; a process for dyeing keratin fibers comprising applying this composition; and the uses of this composition in the form of a dyeing “kit”.

Structure-activity relationship of quinoline derivatives as potent and selective α2c-adrenoceptor antagonists

Starting from two acridine compounds identified in a high-throughput screening campaign (1 and 2, Table 1), a series of 4-aminoquinolines was synthesized and tested for their properties on the human α2- adrenoceptor subtypes (α2A, α2B, and α2C). A number of compounds with good antagonist potencies against the α2C-adrenoceptor and excellent subtype selectivities over the other two subtypes were discovered. For example, (R)-{4-[4-(3,4-dimethylpiperazin-1-yl)phenylamino]quinolin-3-yl}methanol 6j had an antagonist potency of 8.5 nM against, and a subtype selectivity of more than 200-fold for, the α2c-adrenoceptor. Investigation of the structure-activity relationship identified a number of structural features, the most critical of which was an absolute need for a substituent in the 3-position of the quinoline ring. The 3-position on the piperazine ring was also found to play an appreciable role, as substitutions in that position exerted a significant and stereospecific beneficial effect on the α2C- adrenoceptor affinity and potency. Replacing the piperazine ring proved difficult, with 1,4-diazepanes representing the only viable alternative.