863609-11-4

Usage

Chemical class

Triazole derivative

Explanation

The compound belongs to the triazole class of chemicals, which are known for their diverse biological activities.

Explanation

The compound is a methyl ester derivative, which enhances its solubility and bioavailability.

Explanation

Triazoles, in general, are known for their diverse biological activities, which include antimicrobial, antifungal, and anticancer properties.

Explanation

The enhanced solubility and bioavailability of the methyl ester form make it potentially useful for the development of pharmaceutical products.

Explanation

The presence of the 3-chloro-phenyl group attached to the triazole ring may improve the compound's pharmacological properties, making it more effective for medical applications.

Explanation

Additional research and development of 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester could lead to the creation of new pharmaceutical products for a variety of medical applications.

Structure

Methyl ester derivative of 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid

Biological activities

Antimicrobial, antifungal, and anticancer properties

Pharmaceutical applications

Potential use in drug development

3-chloro-phenyl group

Potential enhancement of pharmacological properties

Research and development

Further investigation needed for novel pharmaceutical products

Upstream product

• 63503-60-6 3-chlorophenylboronic acid 
• 4928-88-5 methyl-1H-1,2,4-triazole-5-carboxylate 
• 75998-56-0 Methyl-2-chlor-2-<2-(3-chlorphenyl)hydrazono>acetat 
• 77287-34-4 formamide 
• 4928-88-5 methyl 1H-1,2,4-triazole-3-carboxylate 
• 67-56-1 methanol 
• 127-09-3 sodium acetate 
• 100-77-6 3-chlorobenzenediazonium chloride 
• 624-83-9 methyl isocyanate 

Downstream Products

• 863609-12-5 (1-(3-chlorophenyl)-1H-1,2,4-triazol-3-yl)methanol 
• 90839-68-2 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid 
• 1443758-32-4 {4-[1-(3-chloro-phenyl)-1H-[1,2,4]triazole-3-carbonyl]-2,2-dimethyl-piperazin-1-yl}-(6-methoxy-pyridin-2-yl)-methanone 
• 1443758-33-5 {4-[1-(3-chloro-phenyl)-1H-[1,2,4]triazole-3-carbonyl]-2-ethyl-piperazin-1-yl}-(6-methoxy-pyridin-2-yl)-methanone 
• 1443758-76-6 (S)-{4-[1-(3-chloro-phenyl)-1H-[1,2,4]triazole-3-carbonyl]-3-methyl-piperazin-1-yl}-(6-methoxy-pyridin-2-yl)-methanone 
• 1443758-77-7 (R)-{4-[1-(3-chloro-phenyl)-1H-[1,2,4]triazole-3-carbonyl]-3-methyl-piperazin-1-yl}-(6-methoxy-pyridin-2-yl)-methanone 

Relevant academic research and scientific papers

Monoacylglycerol Lipase Modulators

Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R2, R3 R4, R5 and R6 are defined herein.

Facile One-Pot Synthesis of Methyl 1-Aryl-1H-1,2,4-triazole-3-carboxylates from Nitrilimines with Vilsmeier Reagent

Two convenient and effective one-pot methods have been developed to synthesize methyl 1-aryl-1H-1,2,4-triazole1–3-carboxylates by using hydrazonoyl hydrochlorides (nitrilimines) with Vilsmeier reagent. The first, a direct one-pot method, involved the reac

PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description.

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description.

TRIAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS

The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4 X7, X8, R1, R2, R3, m, n, and p are as defined as in formula (I)