141113-41-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL is used as a potential pharmaceutical compound for its possible biological activity. The triazole group in the compound may allow it to bond with biological targets, making it a candidate for drug development.
Used in Chemical Research:
(R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL is used as a research chemical for studying the effects of its unique structural features on chemical reactivity and stability. The presence of fluorine atoms and the triazole ring may provide insights into the compound's interactions with other molecules and its potential applications in various chemical processes.
Note: The uses listed are speculative based on the structural features of the compound and the common uses of similar compounds in the pharmaceutical and chemical research fields. Further research and testing would be required to confirm the actual applications and properties of (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL.

Upstream product

• 118689-07-9 (S)-(+)-2(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 
• 288-88-0 1,2,4-Triazole 
• 141113-37-3 (S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol 
• 173837-73-5 (S)-2-(2,4-difluorophenyl)-1-isobutyryloxy-3-methanesulfonyloxy-2-propanol 
• 156570-12-6 (S)-3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol 
• 861718-86-7 3-chloro-2-(2,4-difluorophenyl)-2-hydroxypropionaldehyde 
• 861718-85-6 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde 
• 861718-83-4 (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 348-57-2 2,4-difluorobromobenzene 
• 173837-64-4 (R)-2-(2,4-difluorophenyl)-3-isobutyryloxy-1,2-propanediol 
• 149882-16-6 (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 
• 60-29-7 diethyl ether 
• 75-09-2 dichloromethane 

Downstream Products

• 170985-69-0 (R)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol-1-methanesulfonate 
• 170985-70-3 (S)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol-1-methanesulfonate 
• 132507-89-2 (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 
• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Method for asymmetrically opening ring of 3-substituted oxetane and application

The invention discloses a method for catalytically asymmetrically opening a ring of 3-substituted oxetane by using halogen. The method comprises the following steps: with 3-substituted oxetane and a halogen nucleophile as reaction substrates, under the ac

Enantioselective Oxetane Ring Opening with Chloride: Unusual Use of Wet Molecular Sieves for the Controlled Release of HCl

An unprecedented enantioselective oxetane opening with chloride provides access to a range of highly functionalized three-carbon building blocks. The excellent enantiocontrol is enabled not only by a new catalyst, but also by the unusual use of wet molecular sieves for the controlled release of HCl. The enantioselective ring opening of oxetanes with chloride provides access to a range of highly functionalized three-carbon building blocks. The use of a new catalyst in combination with wet molecular sieves for the controlled release of HCl leads to high enantioselectivities.

Asymmetric synthesis, antifungal activity and molecular modeling of iodiconazole isomers

Iodiconazole is a novel antifungal agent that was developed in its racemic form. In order to investigate the effects of the chiral center on the antifungal activity, R- and S-isomers of iodiconazole were prepared on the basis of the asymmetric Sharpless epoxidation. (S)-Iodiconazole was proved to have better antifungal activity than the (R)-isomer. The binding modes of the two isomers with lanosterol 14α-demethylase were clarified by molecular docking. Two isomers of iodiconazole, a novel antifungal agent, were prepared by asymmetric synthesis. Their antifungal activity and binding modes were investigated. Copyright

Catalytic enantioselective synthesis of key intermediates for triazole antifungal agents

(Chemical Equation Presented) A short-step synthesis of versatile chiral building blocks for triazole antifungal agents such as ZD0870 and Sch45450 was developed via catalytic enantioselective cyanosilylation of electron-deficient ketones as the key step.

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two groups convertible in vivo into hydroxy moieties, (e.g., a polyether ester, amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two amino acid ester groups (e.g., an amino acid ester group convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Triazole derivatives

The present invention relates to a novel glycerol derivative and a process for preparing the same, and a process for preparing a triazole derivative. According to the present invention, an optical active 2-arylglycerol derivative which is a novel and useful as a synthetic intermediate of medicament can be provided and furthermore, (R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)-propane-1,2-diol which is useful as an antifungal agent can be prepared.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether ester (e.g., a polyetherester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.