863885-79-4

Basic information

• Product Name: methyl 2-methyl-4-(methylamino)-5-nitrobenzoate
• Synonyms: methyl 2-methyl-4-(methylamino)-5-nitrobenzoate
• CAS NO: 863885-79-4
• Molecular Weight: 224.216
• Mol File: 863885-79-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-methyl-4-(methylamino)-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-methyl-4-(methylamino)-5-nitrobenzoate(863885-79-4)
• EPA Substance Registry System: methyl 2-methyl-4-(methylamino)-5-nitrobenzoate(863885-79-4)

Safety Data

• Hazardous Substances Data: 863885-79-4(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 190367-56-7 methyl 4-chloro-2-methyl-5-nitrobenzoate 
• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 1163287-01-1 methyl 4-fluoro- 2-methyl-5-nitrobenzoate 
• 476660-41-0 4-chloro-2-methyl-5-nitrobenzoic acid 

Relevant articles and documents

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS

Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.