86389-36-8Relevant academic research and scientific papers
A straightforward synthesis of pyrazolines and pyrazoles: Palladium-catalyzed carbonylative vinylation-cyclocondensation reactions of aryl halides
Wu, Xiao-Feng,Neumann, Helfried,Beller, Matthias
experimental part, p. 4919 - 4924 (2011/10/31)
A novel consecutive one-pot synthesis of pyrazolines and pyrazoles starting from simple aryl halides, styrenes, carbon monoxide, and hydrazines has been established. Palladium-catalyzed carbonylative vinylation of aryl halides gave the corresponding chalcones, which are trapped in situ by addition of hydrazines.
Aryl azoles with neuroprotective activity-Parallel synthesis and attempts at target identification
Cocconcelli, Giuseppe,Diodato, Enrica,Caricasole, Andrea,Gaviraghi, Giovanni,Genesio, Eva,Ghiron, Chiara,Magnoni, Letizia,Pecchioli, Elena,Plazzi, Pier Vincenzo,Terstappen, Georg C.
, p. 2043 - 2052 (2008/09/21)
A parallel synthesis of aryl azoles with neuroprotective activity is described. All compounds obtained were evaluated in an in vitro assay using a NMDA toxicity paradigm showing a neuroprotective activity between 15% and 40%. The potential biological target of the active compounds was investigated by extensive literature searches based around similar scaffolds with reported neuroprotective activity. The most interesting molecules active in the NMDA toxicity assay (3a and 2g) showed moderate but significant activity in the inhibition of the Site 2 Sodium Channel binding assay at 10 μM. To confirm our hypothesis compounds 3a, c, f and 2g were tested in the Veratridine assay which is one of the excitotoxicity assays of revelance to NaV channels. The compounds tested showed an activity between 40% and 70%. The identification of neuroprotective small molecules and the identification of NaV channels as the potential site of action were the most important goals of this work.
Heterocycles. 3. Synthesis and Spectral Data of Some 2-Pyrazolines
El-Rayyes, Nizar R.,Hovakeemian, George H.,Hmoud, Hayat S.
, p. 225 - 229 (2007/10/02)
The reaction of 1,3-diaryl-2-propen-1-ones (Ia-o) with hydrazine and methyl- and phenylhydrazine produced different substituted 2-pyrazolines (III).The structures of these products were evident from their chemical and spectroscopic analysis.
Heterocycles. 2 - Regiospecific Addition of Mehtylhydrazine to Acetylenic Ketones
El-Rayyes, N. R.,Hovakeemian, G. H.,Hammoud, H.
, p. 243 - 245 (2007/10/02)
The reaction of 1-p-methoxyphenyl-3-phenyl-2-propen-1-one and 3-p-methoxyphenyl-1-phenyl-2-propen-1-one with methylhydrazine gave 1-methyl-3-p-methoxyphenyl-5-phenylpyrazoline and 1-methyl-3-phenyl-5-p-methoxyphenylpyrazoline, respectively.These compounds
