864076-05-1

Basic information

• Product Name: Methyl 4-broMo-1-Methyl-1H-iMidazole-2-carboxylate
• Synonyms: Methyl 4-broMo-1-Methyl-1H-iMidazole-2-carboxylate;4-bromo-1-methyl-1H-Imidazole-2-carboxylic acid methyl ester
• CAS NO: 864076-05-1
• Molecular Formula: C₆H₇BrN₂O₂
• Molecular Weight: 219.03598
• Mol File: 864076-05-1.mol

Chemical Properties

• Boiling Point: 304.3±34.0 °C(Predicted)
• Appearance: /
• Density: 1.67±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.20±0.60(Predicted)
• CAS DataBase Reference: Methyl 4-broMo-1-Methyl-1H-iMidazole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-broMo-1-Methyl-1H-iMidazole-2-carboxylate(864076-05-1)
• EPA Substance Registry System: Methyl 4-broMo-1-Methyl-1H-iMidazole-2-carboxylate(864076-05-1)

Safety Data

• Hazardous Substances Data: 864076-05-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
Methyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate is employed as a research compound for its potential anti-cancer, anti-inflammatory, and anti-fungal properties. It serves as a valuable tool in the development of new drugs targeting various diseases and conditions.
Used in Organic Synthesis:
In the field of organic synthesis, methyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate is used as a building block. Its unique structure allows it to be incorporated into the synthesis of a wide range of pharmaceutical compounds, contributing to the creation of new molecules with therapeutic potential.
Used in Cancer Treatment Research:
Methyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate is studied for its potential as an anti-cancer agent. It may be utilized in the development of treatments for various types of cancer due to its biological activity.
Used in Inflammation and Fungal Infection Management:
methyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate is also being investigated for its potential to manage inflammation and treat fungal infections, making it a candidate for use in medications aimed at reducing inflammation or combating fungal pathogens.

Upstream product

• 67-56-1 methanol 
• 30148-23-3 2-trichloroacetyl-1-methylimidazole 
• 1313196-09-6 1-(4-bromo-1-methyl-1H-imidazol-2-yl)-2,2,2-trichloroethanone 
• 124-41-4 sodium methylate 

Downstream Products

• 79326-91-3 4-bromo-1-methyl-1H-imidazole-2-carbaldehyde 

Relevant articles and documents

METHOD FOR PRODUCING NITROGEN-CONTAINING AROMATIC AMIDE, METHOD FOR PRODUCING PYRROLE-IMIDAZOLE POLYAMIDE, AND COMPOUND

To provide a method for producing a nitrogen-containing aromatic amide that is capable of using a monomer unit obtained under milder reaction condition and uses catalytic amide bond formation, and a method for producing a pyrrole-imidazole polyamide. [1] A method for producing a nitrogen-containing aromatic amide, including reacting a compound 1 represented by the general formula (1) and a compound 2 represented by the general formula (2) in the presence of a transition metal catalyst and a base, so as to provide a compound 3 represented by the general formula (3). [2] A method for producing a pyrrole-imidazole polyamide, including using the compound 3 obtained by the production method according to the item [1]. [3] A compound represented by the general formula (2aa), the general formula (2ab), the general formula (2ac), or the general formula (2ad).

Synthesis of pyrrole-imidazole polyamide oligomers based on a copper-catalyzed cross-coupling strategy

Pyrrole-imidazole (Py-Im) polyamides are useful tools for chemical biology and medicinal chemistry studies due to their unique binding properties to the minor groove of DNA. We developed a novel method of synthesizing Py-Im polyamide oligomers based on a Cu-catalyzed cross-coupling strategy. All four patterns of dimer fragments could be synthesized using a Cu-catalyzed Ullmann-type cross-coupling with easily prepared monomer units. Moreover, we demonstrated that pyrrole dimer, trimer, and tetramer building blocks for Py-Im polyamide synthesis were accessible by combining site selective iodination of the pyrrole/pyrrole coupling adduct.

INDOLIN-2-ONE DERIVATIVES

The present invention is concerned with indolin-2-one derivatives of general formula (I) wherein the substituents are defined in claim 1. The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of s

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

GAMMA SECRETASE MODULATORS

The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions conta