865444-79-7

Basic information

• Product Name: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE
• Synonyms: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE;4-Chloro-5-methylimidazo[1,5-f][1,2,4]triazine
• CAS NO: 865444-79-7
• Molecular Formula: C₆H₅ClN₄
• Molecular Weight: 168.58
• Mol File: 865444-79-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE(865444-79-7)
• EPA Substance Registry System: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE(865444-79-7)

Safety Data

• Hazardous Substances Data: 865444-79-7(Hazardous Substances Data)

Usage

General Description

4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine is a chemical compound with the molecular formula C4H3ClN6. It is a heterocyclic compound that contains both nitrogen and chlorine atoms, and has a fused ring structure. 4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine is often used as a building block in the synthesis of pharmaceutical drugs and agrochemicals. It is also used as a reagent in organic chemistry reactions, especially in the formation of new carbon-nitrogen bonds. 4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine is known for its versatile reactivity and its ability to participate in a wide range of chemical reactions, making it a valuable intermediate in the production of various compounds.

Upstream product

• 865444-78-6 5-methyl-3H,4H-imidazo[4,3-f][1,2,4]triazin-4-one 

Downstream Products

• 1023758-34-0 N-(4-methoxyphenyl)-N,5-dimethylimidazo[5,1-f][1,2,4]triazin-4-amine 
• 1023758-32-8 N-(3,5-dimethoxyphenyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4-amine 

Relevant articles and documents

N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Disclosed are N-aryl-isoxazolopyrimidin-4-amines and related compounds thereof, represented by the Formula (I): wherein Ar, R1-R5, A, B, D, E, F and H are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

A novel method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-ones

Imidazo[5,1-f][1,2,4]triazinones, as isosteres of purine, are of interest for pharmaceutical research. The syntheses reported in the literature generally require several steps. We report a novel method to access a broad range of diversely substituted derivatives. The key step is the electrophilic N-amination of 3H-imidazoles containing a 4-carbonyl group. Several different substituted imidazoles have been N-aminated in this manner. The resulting N-aminoimidazoles were cyclized under different conditions to the corresponding imidazotriazinones, which allowed for additional diversification. This novel method was applied in a formal synthesis of vardenafil, a well-known representative of this class of compounds. Furthermore, we report the first synthesis of a 7-aryl-imidazotriazinone via bromination of an unsubstituted imidazotriazinone followed by a Suzuki coupling.