866495-00-3Relevant academic research and scientific papers
KRAS G12C Inhibitor compound and application thereof
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, (2021/05/12)
The invention provides a KRAS G12C inhibitor compound and an application thereof, and particularly provides a compound as shown in a formula (I), and an optical isomer, a hydrate, a solvate or pharmaceutically acceptable salt thereof. The compound can be used as a KRAS G12C inhibitor and is used for treating diseases related to the activity or expression quantity of KRAS G12C.
COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS
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, (2019/01/10)
The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.
Stereoselective synthesis of (7aS)-1-methylenehexahydro-1H-pyrrolizine and (-)-heliotridane from N-diphenylmethyl-(S)-proline ethyl ester
Lysenko,Kulinkovich
, p. 70 - 74 (2007/10/03)
Alkaloid (7aS)-1-methylenehexahydro-1H-pyrrolizine was synthesized from N-diphenylmethyl-(S)-proline ethyl ester by cyclopropanation of the ester group with ethylmagnesium bromide in the presence of titanium tetraisopropoxide, replacement of the protectin
