866594-60-7

Basic information

• Product Name: FURO[3,4-B]FURAN-2(3H)-ONE, TETRAHYDRO-4-METHOXY-, (3AS,4S,6AR)-
• Synonyms: FURO[3,4-B]FURAN-2(3H)-ONE, TETRAHYDRO-4-METHOXY-, (3AS,4S,6AR)-;(3aS,4S,6aR)-4-methoxy-tetrahydrofuro[3,4-b]furan-2(3H)-one;(3aS,4S,6aR)-Tetrahydro-4-Methoxyfuro[3,4-b]furan-2(3H)-one;Lacton;FURO[3,4-B]FURAN-2(3H)-ONE, TETRAHYDRO-4-METHOX;4-methoxyfurofuran-2-one
• CAS NO: 866594-60-7
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.15200
• EINECS: 692-063-1
• Product Categories: Chiral Reagents;Heterocycles;Impurities;Intermediates
• Mol File: 866594-60-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 126-128℃ (isopropanol )
• Boiling Point: 311.592°C at 760 mmHg
• Flash Point: 140.55°C
• Appearance: /
• Density: 1.26±0.1 g/cm3 (20 oC 760 Torr), Calc.*
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: FURO[3,4-B]FURAN-2(3H)-ONE, TETRAHYDRO-4-METHOXY-, (3AS,4S,6AR)-(CAS DataBase Reference)
• NIST Chemistry Reference: FURO[3,4-B]FURAN-2(3H)-ONE, TETRAHYDRO-4-METHOXY-, (3AS,4S,6AR)-(866594-60-7)
• EPA Substance Registry System: FURO[3,4-B]FURAN-2(3H)-ONE, TETRAHYDRO-4-METHOXY-, (3AS,4S,6AR)-(866594-60-7)

Safety Data

• Hazardous Substances Data: 866594-60-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Yellow Solid

Uses

(3aS,4S,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one is an impurity of Darunavir (D193500).

InChI:InChI=1/C7H10O4/c1-9-7-4-2-6(8)11-5(4)3-10-7/h4-5,7H,2-3H2,1H3/t4-,5-,7-/m0/s1

Upstream product

• 80923-96-2 ((3aR,4S,6aR)-2-oxohexahydrofuro[3,4-b]furan-4-yl)methyl benzoate 
• 58399-68-1 (3aS,4S,6aR)-2-Oxo-hexahydro-furo[3,4-b]furan-4-carbaldehyde 
• 178557-39-6 ethyl 2-[(3aR,5S,6R,6aR)-5-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-yl]acetate 
• 59256-86-9 ethyl 2-((3aR,5S,6R,6aR)-5-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-yl)acetate 
• 57466-98-5 (Z)-ethyl 2-((3aR,5S,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethylfuro[2,3-d][1,3]dioxol-6(3aH,5H,6aH)-ylidene)acetate 
• 58399-67-0 (3aR,4S,6aR)-4-(hydroxymethyl)tetrahydrofuro[3,4-b]furan-2(3H)-one 
• 866594-61-8 (3aS,4R,6aR)-4-methoxy-tetrahydro-furo[3.4-b]furan-2(3H)-one 
• 67-56-1 methanol 
• 917877-01-1 R-3-(2,2-dimethyl[1,3]dioxolan-4-yl)-acrylic acid ethyl ester 
• 75-52-5 nitromethane 
• 204390-79-4 2-((4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylene)-malonic acid dimethyl ester 
• 36326-38-2 ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 
• 501921-27-3 2-[(R)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-nitro-ethyl]-malonic acid dimethyl ester 
• 124-41-4 sodium methylate 

Downstream Products

• 156928-09-5 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol 

Relevant articles and documents

METHODS FOR MAKING DARUNAVIR P2-LIGAND PRECURSORS

A method for making an optically active P2-ligand precursor comprising converting D-xylose or a derivative thereof or D-glucose or a derivative thereof to the optically active P2-ligand precursor.

METHODS FOR THE PREPARATION OF (3R,3aS,6aR) HEXAHYDRO-FURO[2,3-b]FURAN-3-OL

The present invention relates to methods for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol (6) as well as a novel intermediate, (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one (4) for use in said methods. More in particular the invention relates to a stereoselective method for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol, as well as methods for the crystallization of (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan- 2-one and for the epimerization of (3aR,4R,6aS) 4-methoxy-tetrahydro-furo[3,4-b]-furan-2-one to (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one.