866756-40-3

Upstream product

• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 7154-66-7 2-bromobenzoic acid chloride 
• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 
• 866756-39-0 6,7-dimethoxy-2-(4-methoxybenzyl)-3,4-dihydro-2H-isoquinolin-1-one 
• 866756-37-8 N-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-N-(4-methoxybenzyl)amine 
• 866756-38-9 methyl [2-(2-bromo-4,5-dimethoxyphenyl)ethyl](4-methoxybenzyl)-carbamate 

Relevant academic research and scientific papers

Construction of the six- and five-membered aza-heterocyclic units of the isoindoloisoquinolone nucleus by parham-type cyclization sequences - Total synthesis of nuevamine

An efficient methodology for the synthesis of isoindolo[1,2-α] isoquinolones based on two Parham-type cyclizations allowing the formation of the five- and six-membered nitrogenated rings from carbamate or diacylamine precursors is described. The synthetic potential of this method has been further illustrated by the total synthesis of the alkaloid nuevamine. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.