866897-66-7

Upstream product

• 369405-57-2 N-methoxy-N-methyl-3-(3',4',5'-trimethoxyphenyl)propanamide 
• 25173-72-2 3-(3,4,5-trimethoxyphenyl)propanoic acid 
• 446874-39-1 3-(2-iodo-3,4,5-trimethoxy-phenyl)-N-methoxy-N-methyl-propionamide 
• 1066-54-2 trimethylsilylacetylene 
• 866897-65-6 5-(2-iodo-3,4,5-trimethoxyphenyl)-1-(trimethylsilyl)pent-1-yn-3-one 

Downstream Products

• 866897-68-9 4-{6-[3-(tert-butyl-dimethyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-2,3,4-trimethoxy-phenyl}-4-oxo-butyric acid 
• 866897-67-8 tert-butyl(dimethyl)silyl[(1R)-1-[(2-iodo-3,4,5-trimethoxyphenyl)ethyl]-3-(trimethylsilyl)prop-2-ynyl]ether 

Relevant academic research and scientific papers

Total synthesis of (-)-colchicine via a Rh-triggered cycloaddition cascade

(Chemical Equation Presented) A synthesis of the antimitotic alkaloids (-)-colchicine and (-)-isocolchicine is reported. Important steps are (a) enantioselective transfer-hydrogenation of an alkynone, (b) iodine/magnesium exchange with subsequent aromatic

Total syntheses of colchicine in comparison: A journey through 50 years of synthetic organic chemistry

Colchicine, the major alkaloid of the meadow saffron, is one of the most prominent natural products and, like other tubulin-binding natural products (e.g. taxol and the epothilones), exhibits great pharmaceutical potential. The first syntheses in the late