866897-68-9

Upstream product

• 866897-66-7 (3R)-5-(2-iodo-3,4,5-trimethoxyphenyl)-1-(trimethylsilyl)pent-1-yn-3-ol 
• 866897-65-6 5-(2-iodo-3,4,5-trimethoxyphenyl)-1-(trimethylsilyl)pent-1-yn-3-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 108-30-5 succinic acid anhydride 
• 866897-67-8 tert-butyl(dimethyl)silyl[(1R)-1-[(2-iodo-3,4,5-trimethoxyphenyl)ethyl]-3-(trimethylsilyl)prop-2-ynyl]ether 
• 446874-39-1 3-(2-iodo-3,4,5-trimethoxy-phenyl)-N-methoxy-N-methyl-propionamide 
• 1066-54-2 trimethylsilylacetylene 

Relevant academic research and scientific papers

Total synthesis of (-)-colchicine via a Rh-triggered cycloaddition cascade

(Chemical Equation Presented) A synthesis of the antimitotic alkaloids (-)-colchicine and (-)-isocolchicine is reported. Important steps are (a) enantioselective transfer-hydrogenation of an alkynone, (b) iodine/magnesium exchange with subsequent aromatic