446874-39-1

Upstream product

• 369405-57-2 N-methoxy-N-methyl-3-(3',4',5'-trimethoxyphenyl)propanamide 
• 25173-72-2 3-(3,4,5-trimethoxyphenyl)propanoic acid 
• 66543-72-4 3-(3',4',5'-trimethoxyphenyl)propionyl chloride 

Downstream Products

• 866897-65-6 5-(2-iodo-3,4,5-trimethoxyphenyl)-1-(trimethylsilyl)pent-1-yn-3-one 
• 446874-44-8 1-{6-[3-(tert-butyl-dimethyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-2,3,4-trimethoxy-phenyl}-5-diazo-pentane-1,4-dione 
• 446874-42-6 4-{6-[3-(tert-butyl-dimethyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-2,3,4-trimethoxy-phenyl}-4-oxo-butyric acid 
• 446874-45-9 1-{6-[3-(tert-butyl-dimethyl-silanyloxy)-pent-4-ynyl]-2,3,4-trimethoxy-phenyl}-5-diazo-pentane-1,4-dione 
• 446874-43-7 4-{6-[3-(tert-butyl-dimethyl-silanyloxy)-pent-4-ynyl]-2,3,4-trimethoxy-phenyl}-4-oxo-butyric acid 
• 446874-41-5 1-[3-(tert-butyl-dimethyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-2-iodo-3,4,5-trimethoxy-benzene 
• 446874-40-4 5-(2-iodo-3,4,5-trimethoxy-phenyl)-1-trimethylsilanyl-pent-1-yn-3-ol 
• 866897-67-8 tert-butyl(dimethyl)silyl[(1R)-1-[(2-iodo-3,4,5-trimethoxyphenyl)ethyl]-3-(trimethylsilyl)prop-2-ynyl]ether 
• 866897-66-7 (3R)-5-(2-iodo-3,4,5-trimethoxyphenyl)-1-(trimethylsilyl)pent-1-yn-3-ol 
• 866897-68-9 4-{6-[3-(tert-butyl-dimethyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-2,3,4-trimethoxy-phenyl}-4-oxo-butyric acid 

Relevant academic research and scientific papers

Facile construction of the colchicine skeleton by a rhodium-catalyzed cyclization/cycloaddition cascade

The major alkaloid of the meadow saffron is colchicine, which displays remarkable antimitotic activity and has long been used in the treatment of acute gout and is currently being tested against a broad variety of other diseases. In a remarkable Rh-cataly

Synthesis of indole-derived allocolchicine congeners through Pd-catalyzed intramolecular C-H arylation reaction

The synthesis of several new heterocyclic structural analogs of the natural antimitotic agent allocolchicine is reported. As a key step an intramolecular Pd-catalyzed C-H arylation reaction was used to close the seven-membered ring fused with two electron

Total syntheses of colchicine in comparison: A journey through 50 years of synthetic organic chemistry

Colchicine, the major alkaloid of the meadow saffron, is one of the most prominent natural products and, like other tubulin-binding natural products (e.g. taxol and the epothilones), exhibits great pharmaceutical potential. The first syntheses in the late