446874-39-1Relevant articles and documents
Facile construction of the colchicine skeleton by a rhodium-catalyzed cyclization/cycloaddition cascade
Graening, Timm,Friedrichsen, Willy,Lex, Johann,Schmalz, Hans-Guenther
, p. 1524 - 1526 (2002)
The major alkaloid of the meadow saffron is colchicine, which displays remarkable antimitotic activity and has long been used in the treatment of acute gout and is currently being tested against a broad variety of other diseases. In a remarkable Rh-cataly
Total syntheses of colchicine in comparison: A journey through 50 years of synthetic organic chemistry
Graening, Timm,Schmalz, Hans-Guenther
, p. 3230 - 3256 (2007/10/03)
Colchicine, the major alkaloid of the meadow saffron, is one of the most prominent natural products and, like other tubulin-binding natural products (e.g. taxol and the epothilones), exhibits great pharmaceutical potential. The first syntheses in the late