86731-82-0Relevant articles and documents
Concise synthesis of 1H-pyrazin-2-ones and 2-aminopyrazines
Adam, Isabelle,Orain, David,Meier, Peter
, p. 2031 - 2033 (2007/10/03)
Convenient syntheses of 1H-pyrazin-2-ones and 2-aminopyrazines are described. By coupling Boc-protected amino acids with α-amino ketones or with amino alcohols and subsequent oxidation, 1H-pyrazin-2-ones were obtained. Transformation into the corresponding pyrazine triflates and substitution with primary or secondary amines led to 2-aminopyrazines. Since these syntheses take advantage of the use of readily available starting materials (e.g., amino acids, aminoalcohols and amines) a variety of the entitled structures can be obtained in few, high yielding steps.
Reactions of the Monoxides of 2,6-Disubstituted Pyrazines with Phosphoryl Chloride and Acetic Anhydride
Ohta, Akihiro,Imazeki, Akiko,Itoigawa, Yohko,Yamada, Hiroko,Suga, Chieko,et al.
, p. 311 - 320 (2007/10/02)
The monoxides of 2,6-dimethyl- (1), 2,6-diphenyl- (2), and 2-methyl-6-phenylpyrazines (3) were subjected to the reactions with phosphoryl chloride and acetic anhydride.Some reactions of the chloropyrazines and hydroxypyrazines obtained thus were also inve
