86767-33-1

Basic information

• Product Name: 1-phenyl-1-(4-(trifluoroMethyl)phenyl)ethanol
• Synonyms: 1-phenyl-1-(4-(trifluoroMethyl)phenyl)ethanol;alpha-Methyl-alpha-phenyl-4-(trifluoromethyl)benzenemethanol
• CAS NO: 86767-33-1
• Molecular Formula: C₁₅H₁₃F₃O
• Molecular Weight: 266.2583296
• Mol File: 86767-33-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.225
• CAS DataBase Reference: 1-phenyl-1-(4-(trifluoroMethyl)phenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1-(4-(trifluoroMethyl)phenyl)ethanol(86767-33-1)
• EPA Substance Registry System: 1-phenyl-1-(4-(trifluoroMethyl)phenyl)ethanol(86767-33-1)

Safety Data

• Hazardous Substances Data: 86767-33-1(Hazardous Substances Data)

Usage

Appearance

White crystalline powder This describes the physical form and color of the compound, which is important for its identification and handling.

Aromatic alcohol

Substituted aromatic compound The compound contains both a hydroxyl functional group (-OH) and an aromatic ring, which classifies it as an aromatic alcohol. This property influences its chemical reactivity and potential applications.

Chemical reactivity

Participates in various chemical reactions The presence of the hydroxyl group and the aromatic ring allows the compound to engage in a wide range of chemical reactions, making it useful in organic synthesis and pharmaceutical research.

Applications

Production of pharmaceuticals, agrochemicals, and specialty chemicals Due to its versatile chemical properties, 1-phenyl-1-(4-(trifluoroMethyl)phenyl)ethanol is used in the creation of various products, including medications, pesticides, and other specialized chemical compounds.

Value in organic chemistry and drug discovery

Unique properties and versatile nature The compound's distinctive characteristics and adaptability make it a valuable resource for researchers and chemists working in the fields of organic chemistry and drug development.

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 98-80-6 phenylboronic acid 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-58-3 phenylmagnesium bromide 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 98-86-2 acetophenone 

Downstream Products

• 898282-29-6 N-(1-(4-(trifluoromethyl)phenyl)ethylidene)aniline 
• 1202853-73-3 1-phenyl-1-(4-(trifluoromethyl)phenyl)ethan-1-amine 
• 60921-51-9 4-Nitro-benzoic acid 1-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl ester 
• 60665-79-4 Methylphenyl-p-trifluorphenylcarbenium-Ion 
• 128270-96-2 2-(4'-nitrophenyl)-3-ethyl-2,3-bis-<4''-(trifluoromethyl)phenyl>pentane 
• 128270-98-4 2-<4'-(trifluoromethyl)phenyl>-2-(4''-nitrophenyl)-3-ethyl-3-(4'''-fluorophenyl)pentane 

Relevant articles and documents

Synthesis and application of 2,6-bis(trifluoromethyl)-4-pyridyl phosphanes: The most electron-poor aryl phosphanes with moderate bulkiness

The poor will be rich: BFPy phosphanes (see scheme) mimic the electronic and steric characters of P(C6F5)3 and PPh 3, respectively. These novel ligands showed a large ligand acceleration effect on Stille coupling, the Rh-catalyzed 1,2-addition of aryl boronic acid to unactivated ketones and the asymmetric arylation of N-tosylimine using phenylboronic acid. Copyright

Highly enantioselective arylation of aldehydes and ketones using AlArEt2(THF) as aryl sources

A series of AlArEt2(THF) (Ar = Ph (la), 4-MeC6H 4 (1b), 4-MeOC6H 4 (1c), 4-Me 3SiC6H4 (1d), 2-naphthyl (le)) were synthesized from reactions of AlEt2Br(THF) with ArMgBr. In CDC13 solution, the 1H NMR spectra showed that AlArEt2(THF) compounds exist as a mixture of four species of formulas of AlAr xEt3-x (THF) (x = 0, 1, 2, or 3). AlArEt2(THF) compounds were found to be superior and atom-economic reagents for asymmetric aryl additions to organic carbonyls. Aryl additions of AlArEt2(THF) to aldehydes catalyzed by the titanium(IV) complex of (R)-H8-BINOL were efficient with a short reaction time of 1 h, affording aryl addition products as exclusive or main products in high yields and excellent enantioselectivities of up to 98% ee. Although ethyl additions to aldehydes occurred in minor extent, this study demonstrates that increasing the amount of AlArEt2(THF) from 1.2 to 1.4 or to 1.6 equiv significantly improved the aryl addition products of up to >99%. On the other hand, asymmetric arylations of AlArEt2(THF) to ketones employing a titanium(IV) catalyst of (S)-BINOL produced optically active tertiary alcohols exclusively in excellent enantioselectivities of up to 94% ee.