868285-96-5Relevant academic research and scientific papers
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
-
Paragraph 001008, (2017/08/01)
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Synthesis of a homologous series of side-chain-extended orthogonally protected aminooxy-containing amino acids
Liu, Fa,Thomas, Joshua,Burke Jr., Terrence R.
experimental part, p. 2432 - 2438 (2009/04/11)
Practical methodology is reported for the synthesis of a homologous series of side-chain-extended amino acids containing aminooxy functionality bearing orthogonal protection suitable for Fmoc peptide synthesis. These reagents may be useful for the preparation of libraries containing fragments joined by peptide linkers. Georg Thieme Verlag Stuttgart.
