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868359-05-1

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE, also known as WAY 213613, is a selective non-substrate inhibitor of EAAT2, a glutamate transporter protein. It is a synthetic compound with a complex chemical structure that has potential applications in the field of neurodegenerative diseases.
Used in Pharmaceutical Industry:
N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE is used as a therapeutic agent for treating or inhibiting the onset of Huntington's disease, a progressive neurodegenerative disorder. It functions by modulating the activity of EAAT2, which plays a crucial role in maintaining the balance of extracellular glutamate levels in the brain. By inhibiting EAAT2, WAY 213613 may help reduce the excitotoxic effects of excessive glutamate, thereby slowing down the progression of Huntington's disease.
Additionally, N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE can be used in combination with gene modulatory compounds to enhance its therapeutic effects and potentially develop novel treatment strategies for Huntington's disease and other related neurodegenerative conditions.

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  • 868359-05-1 Structure

  • Basic information

    1. Product Name: N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE
    2. Synonyms: N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE;WAY 213613;N4-[4-(2-Bromo-4,5-difluorophenoxy)phenyl)]-L-asparagine
    3. CAS NO:868359-05-1
    4. Molecular Formula: C16H13BrF2N2O4
    5. Molecular Weight: 415.19
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 868359-05-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 565.634°C at 760 mmHg
    3. Flash Point: 295.885°C
    4. Appearance: /
    5. Density: 1.665g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.632
    8. Storage Temp.: Desiccate at RT
    9. Solubility: DMSO: >10mg/mL
    10. PKA: 2.38±0.10(Predicted)
    11. CAS DataBase Reference: N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE(868359-05-1)
    13. EPA Substance Registry System: N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE(868359-05-1)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. RIDADR: UN 2811 6.1 / PGIII
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 868359-05-1(Hazardous Substances Data)

868359-05-1 Usage

Biological Activity

Potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC 50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.

Check Digit Verification of cas no

The CAS Registry Mumber 868359-05-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,3,5 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 868359-05:
(8*8)+(7*6)+(6*8)+(5*3)+(4*5)+(3*9)+(2*0)+(1*5)=221
221 % 10 = 1
So 868359-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1

868359-05-1 Well-known Company Product Price

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  • Sigma

  • (W0145)  WAY-213613  ≥98% (HPLC)

  • 868359-05-1

  • W0145-5MG

  • 2,013.57CNY

  • Detail

  • Sigma

  • (W0145)  WAY-213613  ≥98% (HPLC)

  • 868359-05-1

  • W0145-25MG

  • 7,780.50CNY

  • Detail

868359-05-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid

1.2 Other means of identification

Product number -
Other names WAY-213,613

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:868359-05-1 SDS

868359-05-1Downstream Products

868359-05-1Relevant articles and documents

Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Greenfield, Alexander,Grosanu, Cristina,Dunlop, John,McIlvain, Beal,Carrick, Tikva,Jow, Brian,Lu, Qiang,Kowal, Dianne,Williams, John,Butera, John

, p. 4985 - 4988 (2005)

Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions. A complete elucidation of the functional role of EAAT-2 has been hampered by the lack of potent and selective pharmacological tools. In this study, we describe the synthesis and biological activities of novel aryl-ether, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT-2. Compound (16) represents one of the most potent (IC50 = 85 ± 5 nM) and selective inhibitors of EAAT-2 identified to date.

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