869676-91-5

Usage

Main Uses

Building Block: Primarily utilized in the synthesis of various pharmaceuticals and agrochemicals.
Intermediate: Used in the production of dyes, pigments, and other specialty chemicals.
Versatile chemical reactivity
Potential for developing novel chemical products and applications.

Upstream product

• 166281-37-4 2-bromo-4,5-difluorophenol 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 868359-05-1 N-[4-(2-bromo-4,5-difluorophenoxy)phenyl]-L-asparagine 

Relevant academic research and scientific papers

Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions. A complete elucidation of the functional role of EAAT-2 has been hampered by the lack of potent and selective pharmacological tools. In this study, we describe the synthesis and biological activities of novel aryl-ether, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT-2. Compound (16) represents one of the most potent (IC50 = 85 ± 5 nM) and selective inhibitors of EAAT-2 identified to date.