868522-73-0Relevant academic research and scientific papers
GLYCOSIDASE INHIBITORS AND USES THEREOF
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Paragraph 00136, (2014/03/25)
The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related t
Efficient synthesis from d-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-l-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases
Rountree, J.S.Shane,Butters, Terry D.,Wormald, Mark R.,Dwek, Raymond A.,Asano, Naoki,Ikeda, Kyoko,Evinson, Emma L.,Nash, Robert J.,Fleet, George W.J.
, p. 4287 - 4291 (2008/02/12)
The synthesis from d-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-l-arabinitol LABNAc proceeded in an overall yield of 25%; the enantiomer, 2-acetamido-1,4-imino-1,2,4-trideoxy-d-arabinitol DABNAc, was prepared from l-lyxonolactone. LABNAc and N-
