86870-31-7

Upstream product

• 3483-19-0 3-(4-methylphenyl)sydnone 
• 68-12-2 N,N-dimethyl-formamide 
• 93-61-8 N-methyl-N-phenylformamide 
• 52827-02-8 2-(nitroso(p-tolyl)amino)acetic acid 
• 21911-69-3 N-(p-tolyl)glycine 
• 21911-68-2 ethyl 2-(p-tolylamino)acetate 
• 106-49-0 p-toluidine 

Downstream Products

• 397884-34-3 3-(4-methylphenyl)sydnon-4-ylformaldehyde α-chloroformyl4-methylphenylhydrazone 

Relevant academic research and scientific papers

Novel sydnone derivatives carrying azidomethyl-1,2, 4-oxadiazole unit and their 1,3-dipolar cycloadditions

A series of 1,2,4-oxadiazolymethyl sydnones carrying azido group were synthesized and subjected to react with a variety of alkenic and acetylenic dipolarophilic reagents; N-phenyl maleimide, phenyl vinyl sulfone, and phenyl propiolic acid. All the new products are identified by spectral/physical data including high-resolution mass measurements and X-ray diffraction data.

Design, docking studies and molecular iodine catalyzed synthesis of benzo[a]xanthen-one derivatives as hyaluronidase inhibitors

A series of novel benzo[a]xanthen-11(12H)-one derivatives 4a–m were designed and subjected to docking studies. The title compounds were synthesized from 3-aryl-4-formylsydnones 1a–m, β-naphthol and dimedone in presence of molecular iodine as a catalyst an

Reaction of some substituted 3-aryl-4-formylsydnones with tetra-oacetyl-β-d-galactopyranosyl)thiosemicarbazide

Background: Thiosemicarbazones containing mono- or disaccharide moieties reveal several various remarkable biological activities; therefore these compounds have been focused in organic syntheses. Sydnone ring is the potential basic pharmacodynamic nucleus

Synthesis of novel imidazo[2,1-b][1,3,4]thiadiazoles appended to sydnone as anticancer agents

A novel series of 3-aryl-4{6′-(6′′-substituted-coumarin- 3′′-yl) imidazo[2,1-b][1,3,4]thiadiazol-2′-yl}-sydnones 5h-5s were synthesized and screened for their anticancer and DNA cleavage activities and analyzed for pharmacological parameters such as toxicity, drug-likeliness, and drug score for oral bioavailability. In vitro toxicity assay was carried out by assessing the survival E. coli AB1157 (wild type) cultures. Some of the compounds have shown significant anticancer activities also.

Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone

A novel series of 1-substituted aminomethyl-3-[1-(4-isobutylphenyl)ethyl]- 4-(3-aryl-4-sydnonylidene) amino-1,2,4-triazol-5-thiones (9), was prepared from the 3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino 5-mercapto-1,2,4-triazoles (8) by aminomethylation with formaldehyde and secondary amine. The structures of Schiff bases (8) and Mannich bases (9) were characterized on the basis of IR, NMR, mass spectra1 data and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Mannich bases (9) carrying piperidine and morpholine residues showed promising anti-inflammatory and analgesic activity.

Synthesis of novel 2-(3′-aryl-sydnon-4′-ylidene)-5′- substituted-[1,3,4]-thiadiazolylamines and [1,3,4]-thiadiazol-2′-yl-3-oxo- [1,2,4]-triazoles as antimicrobial agents

The title compounds (3g-n) and (6g-n) were synthesized using 3-arylsydnones as synthons, and the structures were confirmed by IR, 1H NMR, FAB mass and CHN analysis. These compounds were evaluated for their antibacterial and the antifungal activ

Synthesis and characterization of new electroluminescent materials of 1,3,4-oxadiazole-1,2,3-triazole hybrids and 1,3,4-oxadiazole-1,2,3-triazole- pyridine derivatives

New electroluminescent materials of 1,3,4-oxadiazole-1,2,3-triazole and 1,3,4-oxadiazole-1,2,3-triazole-pyridine hybrid derivatives were synthesized and characterized. Following spectroscopic studies and characterization of their electronic properties, 1,

Synthesis and characterization of potential efficient electroluminescent materials: 2-Phenyl-5-[4-(4-phenylamino-2H-1,2,3-triazol-2-yl)]phenyl-1,3,4- oxadiazole derivatives

Recently, 1,3,4-oxadiazole-based on heterocyclic compounds were investigated as electroluminescent materials. In this work, we first introduce 1,2,3-triazole to synthesize a series of 1,3,4-oxadiazole-1,2,3-triazole hybrids derivatives as potential electr