868736-12-3

Basic information

• Product Name: Benzene, 1,4-difluoro-2-nitro-5-(phenylmethoxy)-
• CAS NO: 868736-12-3
• Molecular Formula: C13H9F2NO3
• Molecular Weight: 265.216
• Mol File: 868736-12-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1,4-difluoro-2-nitro-5-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,4-difluoro-2-nitro-5-(phenylmethoxy)-(868736-12-3)
• EPA Substance Registry System: Benzene, 1,4-difluoro-2-nitro-5-(phenylmethoxy)-(868736-12-3)

Safety Data

• Hazardous Substances Data: 868736-12-3(Hazardous Substances Data)

Upstream product

• 2105-61-5 1,2,4-trifluoro-5-nitrobenzene 
• 100-51-6 benzyl alcohol 

Downstream Products

• 120103-19-7 4-amino-2,5-difluorophenol 
• 928038-46-4 Benzyl [4-(4-aminopyrimidin-6-yloxy)-2,5-difluorophenyl]carbamate 
• 928038-47-5 Benzyl [4-(4-azidopyrimidin-6-yloxy)-2,5-difluorophenyl]carbamate 
• 928038-45-3 benzyl [4-(4-chloropyrimidin-6-yloxy)-2,5-difluorophenyl]carbamate 
• 871681-62-8 (2,5-difluoro-4-hydroxy-phenyl)-carbamic acid benzyl ester 
• 928038-49-7 N-{4-[(4-Aminopyrimidin-6-yl)oxy]-2,5-difluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1552280-93-9 4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2,5-difluorophenoxy)picolinamide 
• 868736-13-4 4-(4-amino-2,5-difluorophenoxy)picolinamide 
• 1275153-32-6 C₁₃H₁₁F₂NO 

Relevant articles and documents

SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE

A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen.

NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)

A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.]