868840-76-0

Upstream product

• 18342-66-0 2,5-dioxopyrrolidin-1-yl methylcarbamate 
• 119831-72-0 Fmoc-Arg(Pbf)-OH 
• 129460-09-9 Fmoc-Asp-O-t-Bu 
• 868840-74-8 C₄₉H₇₄N₈O₁₃S 
• 868840-75-9 C₄₉H₇₂N₈O₁₂S 

Downstream Products

• 243975-37-3 cyclo(N^w-(N-methylcarbamoyl)-L-arginyl-N-methyl-L-phenylalanyl-β-L-aspartyl-β-L-aspartyl-D-alanyl) 

Relevant academic research and scientific papers

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

A new, highly efficient, all-solid-phase synthesis of argifin, a natural product cyclic pentapeptide chitinase inhibitor, is reported. The synthesis features attachment of an orthogonally protected Asp residue to the solid support and assembly of the line

An efficient synthesis of argifin: A natural product chitinase inhibitor with chemotherapeutic potential

The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.