869062-10-2Relevant articles and documents
Modular total synthesis of rhizopodin: A highly potent G-actin dimerizing macrolide
Kretschmer, Manuel,Dieckmann, Michael,Li, Pengfei,Rudolph, Sven,Herkommer, Daniel,Troendlin, Johannes,Menche, Dirk
, p. 15993 - 16018 (2014/04/03)
A highly convergent total synthesis of the potent polyketide macrolide rhizopodin has been achieved in 29steps by employing a concise strategy that exploits the molecule′s C2 symmetry. Notable features of this convergent approach include a rapid assembly of the macrocycle through a site-directed sequential cross-coupling strategy and the bidirectional attachment of the side chains by means of Horner-Wadsworth-Emmons (HWE) coupling reactions. During the course of this endeavor, scalable routes for synthesis of three main building blocks of similar complexity were developed that allowed for their stereocontrolled construction. This modular route will be amenable to the development of syntheses of other analogues of rhizopodin.
Atom-economic and stereoselective syntheses of the ring A and B subunits of the bryostatins
Trost, Barry M.,Yang, Hanbiao,Brindle, Cheyenne S.,Dong, Guangbin
, p. 9777 - 9788 (2011/10/05)
This article describes chemoselective and atom-economic methods for the stereoselective assembly of the ring A and B subunits of bryostatins. A Ru-catalyzed tandem alkene-alkyne coupling/Michael addition reaction was developed and applied to the synthesis
A Ru-catalyzed tandem alkyne-enone coupling/Michael addition: Synthesis of 4-methylene-2,6-cis-tetrahydropyrans
Trost, Barry M.,Yang, Hanbiao,Wuitschik, Georg
, p. 4761 - 4764 (2007/10/03)
(Chemical Equation Presented) A Ru-catalyzed tandem alkyne-enone coupling/Michael addition reaction is reported. It provides an efficient, atom-economic entry to 4-methylene-2,6-cis-tetrahydropyrans from simple, readily available homopropargylic alcohols