92156-87-1

Upstream product

• 75-09-2 dichloromethane 
• 446264-36-4 3-[(4-methoxyphenyl)methoxy]-2,2-dimethyl-propan-1-ol 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 136358-40-2 <1(1R,3R,4R),1E,3S>-3-hydroxy-5-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4,4-trimethyl-1-pentene 
• 136457-93-7 <1(1R,3R,4R),1E,3R>-3-hydroxy-5-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4,4-trimethyl-1-pentene 
• 502430-33-3 ethyl 5-(4-methoxybenzyloxy)-4,4-dimethylpent-2-enoate 
• 853296-64-7 1-(4,4-dibromo-2,2-dimethyl-but-3-enyloxymethyl)-4-methoxy-benzene 
• 934631-59-1 1-{[[2,2-dimethyl-3-butyn-1-yl]oxy]methyl}-4-methoxybenzene 
• 102092-57-9 7,7-dimethyl-8-(4-methoxyphenyl)methoxy-5(Z)-octenoic acid 
• 1303556-24-2 (R)-(E)-ethyl 5-hydroxy-7-(4-methoxybenzyloxy)-6,6-dimethylhept-2-enoate 
• 1335128-66-9 (R)-1-(4-methoxybenzyloxy)-2,2,5-trimethylhex-5-en-3-ol 
• 885674-86-2 (S)-1-(4-methoxybenzyloxy)-2,2-dimethylhex-5-en-3-ol 
• 885674-97-5 C₆₁H₈₀N₂O₁₃Si 
• 885675-17-2 C₅₅H₆₆N₂O₁₃ 
• 885674-96-4 2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid 
• 885674-92-0 2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid methyl ester 
• 885674-94-2 2-[(3E,7Z)-(2R,10S)-10-Hydroxy-2-methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Second basic pKa: An overlooked parameter in predicting phospholipidosis-inducing potential of diamines

In this paper, we present the phospholipidosis-inducing potential (PLIP) of forty fragment-sized diamines derived from N-benzyl-4-(methylamino)piperidine and discuss the relationship between their PLIP and the physicochemical properties. Our results demonstrate that the previously reported methods are not suitable for predicting the PLIP of fragment-sized diamines; the second basic pKa can distinguish PLIP-positive diamines from PLIP-negative diamines more accurately than ClogP or most basic pKa. To the best of our knowledge, this is the first report describing the relationship between PLIP and second basic pKa.

4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT

There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or phamaceutically acceptable salts thereof; the derivatives have a superior EP4 receptor antagonistic action and are useful as pharmaceuticals for the trea

4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT

There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or phamaceutically acceptable salts thereof; the derivatives have a superior EP4 receptor antagonistic action and are useful as pharmaceuticals for the trea

Distinct chemoselectivities in the platinum-catalyzed 1,2- carboalkoxylations of 5-alkoxypent-1-yn-3-ol derivatives

Two distinct Pt-catalyzed carboalkoxylations of alkynes are reported. The cycloisomerization of 5-alkoxypent-1-yn-3-ol derivatives 5 produces 2,6-dioxabicyclo[3.1.0]hexanes 6; the mechanism is postulated to involve a hydroxyl-triggered [3.3]-sigmatropic a

Atom-economic and stereoselective syntheses of the ring A and B subunits of the bryostatins

This article describes chemoselective and atom-economic methods for the stereoselective assembly of the ring A and B subunits of bryostatins. A Ru-catalyzed tandem alkene-alkyne coupling/Michael addition reaction was developed and applied to the synthesis

A Ru-catalyzed tandem alkyne-enone coupling/Michael addition: Synthesis of 4-methylene-2,6-cis-tetrahydropyrans

(Chemical Equation Presented) A Ru-catalyzed tandem alkyne-enone coupling/Michael addition reaction is reported. It provides an efficient, atom-economic entry to 4-methylene-2,6-cis-tetrahydropyrans from simple, readily available homopropargylic alcohols

Toward the synthesis of peloruside A: Fragment synthesis and coupling studies

(Matrix presented). The asymmetric synthesis of building blocks 3, 4, and 5, corresponding to C12-C19, C7-C 11, and C1-C6 segments of peloruside A, is reported, along with boron-mediated al

Conformational analysis of oligo-1,3-dioxanylmethanes

Stereoselective synthesis of a series of 1,3-dioxan-4-ylmethanes 1-9 has been achieved by use of solely substrate-based asymmetric induction. The simple C2-symmetric bis(dioxanyl)methane 1 has a greater than 99% conformational preference at the two inter-ring bonds for the conformation 1a. The homologous structures 3-9 contain up to five dioxanylmethane units, maintaining a high conformational preference in each of the bis(dioxanyl)methane units. Thus, these flexible compounds reach a conformational preference in excess of 90% over up to eight rotatable interring bonds. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

Aryl fatty acid leukotriene synthesis inhibitors

Aryl fatty acid compounds of the formula (I) STR1 wherein R1, R2, R3, X, and Y are as defined herein are novel and useful in the treatment of allergic and inflammatory disorders.