86918-09-4

Basic information

• Product Name: N-(hexan-2-yl)benzamide
• CAS NO: 86918-09-4
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.2961
• Mol File: 86918-09-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 359.6°C at 760 mmHg
• Flash Point: 216.4°C
• Density: 0.965g/cm³
• Vapor Pressure: 2.35E-05mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: N-(hexan-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(hexan-2-yl)benzamide(86918-09-4)
• EPA Substance Registry System: N-(hexan-2-yl)benzamide(86918-09-4)

Safety Data

• Hazardous Substances Data: 86918-09-4(Hazardous Substances Data)

Upstream product

• 592-41-6 1-hexene 
• 55-21-0 benzamide 
• 110-54-3 hexane 
• 582-61-6 benzoyl azide 
• 98-88-4 benzoyl chloride 
• 68107-05-1 1-Methyl-pentylamin 

Relevant articles and documents

Chiral 2-imidazoline aniline compound as well as preparation method and application thereof

The invention provides a chiral 2-imidazoline aniline compound as well as a preparation method and application thereof. The preparation method comprises the following steps: reacting an o-nitrobenzoic acid compound as shown in a formula (1), oxalyl chloride and N, N-dimethylformamide to obtain an o-nitrobenzoyl chloride compound as shown in a formula (7); adding the hydroxyl amide derivative into a mixed solution of an amino alcohol compound as shown in a formula (2) and triethylamine to obtain a hydroxyl amide derivative as shown in a formula (3); reacting with thionyl chloride to obtain a dichloro compound as shown in a formula (4); then adding triethylamine and primary amine R2NH2 to prepare a nitroimidazoline derivative; and finally, reducing to obtain the chiral 2-imidazoline aniline compound as shown in a formula (6). The chiral 2-imidazoline aniline compound is easy to prepare, the raw materials are cheap and easy to obtain, the preparation method is simple, and the synthesized chiral ligand containing the 2-imidazoline aniline fragment can be used as a catalyst for catalyzing asymmetric hydroboration reaction of cobalt-catalyzed olefin and asymmetric hydroamination reaction of cobalt-catalyzed non-activated terminal olefin.

Copper-Catalyzed C(sp3)?H Amidation: Sterically Driven Primary and Secondary C?H Site-Selectivity

Undirected C(sp3)?H functionalization reactions often follow site-selectivity patterns that mirror the corresponding C?H bond dissociation energies (BDEs). This often results in the functionalization of weaker tertiary C?H bonds in the presence of stronger secondary and primary bonds. An important, contemporary challenge is the development of catalyst systems capable of selectively functionalizing stronger primary and secondary C?H bonds over tertiary and benzylic C?H sites. Herein, we report a Cu catalyst that exhibits a high degree of primary and secondary over tertiary C?H bond selectivity in the amidation of linear and cyclic hydrocarbons with aroyl azides ArC(O)N3. Mechanistic and DFT studies indicate that C?H amidation involves H-atom abstraction from R-H substrates by nitrene intermediates [Cu](κ2-N,O-NC(O)Ar) to provide carbon-based radicals R. and copper(II)amide intermediates [CuII]-NHC(O)Ar that subsequently capture radicals R. to form products R-NHC(O)Ar. These studies reveal important catalyst features required to achieve primary and secondary C?H amidation selectivity in the absence of directing groups.